Associate Professor, Anesthesiology & Perioperative Medicine, University of Missouri

Dr. George R. Kracke is a cell physiologist with research interests in neurophysiology and pain mechanisms.  He collaborates with a team of chemists at the University of Missouri International Institute of Nano and Molecular Medicine to produce and test novel molecules with potential analgesic and anesthetic activity.

Dr. Kracke is an Associate Professor in the Department of Anesthesiology and Perioperative Medicine at the University of Missouri School of Medicine and an adjunct faculty member in the International Institute of Nano and Molecular Medicine.  In addition to research he teaches at the University of Missouri School of Medicine and is a block director.

 

George Kracke

George Kracke

(573) 884-8520

krackeg@missouri.edu

Research Area:

Cell physiology, structure activity relationships of drugs and receptors

Research Interests:

We are interested in developing new, boron based drugs that target nerve cells. Our focus is on ion channels and ligand receptors located in the neuronal plasma membrane. We express these proteins in heterologous cells and study them functionally using techniques of cell physiology such as whole cell voltage clamp. Our goal is to develop pharmaceuticals that have distinct advantages over existing drugs affecting the central and peripheral nervous systems.

Education

B.A. Biophysics, The Johns Hopkins University, Baltimore, MD, 1970
M.A. Physiology State University of New York at Buffalo, Buffalo, NY, 1974
Ph.D. Drexel University College of Medicine (formerly Medical College of Pennsylvania), Philadelphia, PA, 1979

Awards

1980 Grass Foundation Fellowship, Marine Biological Laboratory, Woods Hole, Massachusetts.
2008 Order of Socrates II teaching award for contributions to the MU medical curriculum.

Selected Publications

Johnson, G.A., Gutti, V.R., Loyalka, S.K., O’Beirne, K.A., Cochran, S.K., Dale, H.M., Kracke, G.R.  Albuterol metered dose inhaler performance under hyperbaric pressures.  Undersea and Hyperbaric Medical Society Journal.  36:55-63, 2009.

Rodvelt, K.R., Schachtman, T.R., Kracke, G.R., and Miller, D.K. NMDA receptor blockade augmented nicotine-evoked dopamine release from rat prefrontal cortex slices.  Neuroscience Letters.  440:319-22, 2008.

Rodvelt, K.R., Kracke, G.R., Schachtman, T.R., and Miller, D.K.  Ketamine induces hyperactivity in rats and hypersensitivity to nicotine in rat striatal slices.  Pharmacology, Biochemistry and Behavior. 91:71-6, 2008.

Miller, D.K., Lever, J.R., Rodvelt, K.R., Baskett, J.A., Will, M.J., Kracke, G.R.  Lobeline, A Potential Pharmacotherapy for Drug Addiction, Binds to μ Opioid Receptors and Diminishes the Effects of Opioid Receptor Agonists.  Drug and Alcohol Dependence 89: 282-291, 2007.

Kracke, G.R., Stoneking, S.P., Ball, J.M., Washington, C.C., Johnson, J.O., Tobias, J.D.  The cannabinoid receptor agonists, anandamide and WIN 55,212-2, do not directly affect mu opioid receptors expressed in Xenopus oocytes.  Naunyn-Schmiedeberg Archives of Pharmacology, 376:285-293, 2007.   

Kracke, G.R., Uthoff, K.A., and Tobias, J.D.  Sugar Solution Analgesia: The Effects of Glucose on Expressed Mu Opioid Receptors.  Anesthesia and Analgesia, 101:64-8, 2005