Associate Professor and Associate Head (Research), The University of Sydney

Lou Rendina leads the Bioinorganic Medicinal Chemistry group in the School of Chemistry, The University of Sydney, Australia. He is also the Associate Head (Research). He is the recipient of several research awards and international fellowships, including two prestigious national awards from the Royal Australian Chemical Institute (RACI) for his seminal contributions to the areas of Medicinal Chemistry (RACI Biota Medal for Medicinal Chemistry) and Organometallic Chemistry (RACI Organometallic Chemistry Award), the only individual to have ever received both awards. He is a Fellow of the RACI (FRACI, C. Chem.) and a Fellow of the Royal Society of Chemistry, UK (FRSC). In 2014, he was appointed to the Australian Research Council (ARC) College of Experts.

 

 

 

Louis Rendina Photo

Research Interests

Under Construction

Education

B.Sc.(Hons I) ANU.
Ph.D. ANU. Thesis: “Diplatinum Complexes as Anticancer Drugs”.

Awards

2014 - 2016  Appointed to the Australian Research Council (ARC) College of Experts.
2008  Royal Society JWT Jones Fellowship (Oxford University).
2008   The University of Osaka Visiting Professorship.
2005   Selby Research Award.
2004   Royal Australian Chemical Institute Organometallic Chemistry Award.
2003   Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry.
1993-1995  Natural Sciences & Engineering Research Council (NSERC)
 Canada International Fellowship.
1991-1993  ANU–IAS Postdoctoral Fellowship.
1991  &nmsp;Albert, Birch, and Craig Award (for most outstanding PhD thesis).
1988-1990  Commonwealth Postgraduate Research Award. 


Selected Publications

71. Kahlert, J. U.; Rawal, A.; Hook, J.; Rendina, L. M.; Choucair, M. “Facile Carborane Functionalization of Graphene”, Chem. Commun., submitted.

70. Morrison, D. E.; Aitken, J. B.; de Jonge, M. D.; Issa, F.; Harris. H. H.; Rendina, L. M. “Synthesis and Biological Evaluation of a New Class of Mitochondria-Targeted Gadolinium(III) Agents”, Chem. Eur. J., in press.

69. Wilkinson, S. M.; Gunosewoyo, H.; Barron, M. L.; Boucher, A.; McDonnell, M.; Turner, P.; Morrison, D. E.; Bennett, M. R.; McGregor, I. S.; Rendina, L. M.; Kassiou, M. “The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist With Antidepressant Activity”, ACS Chem. Neuroscience, 2014, 5, 335–339.

68. Austin, C. J. D.; Kahlert, J.; Issa, F.; Ioppolo, J. A.; Reed, J. H.; Ong, J. A.; Smith, J. R.; Jamie, J. F.; Hibbs, D.; Rendina, L. M. “The First Indoleamine-2,3-dioxygenase- 1 (IDO1) Inhibitors Containing Carborane”, Dalton Trans., 2014, 43, 10719-10724. [Invited article]

67. Morrison, D. E.; Aitken, J. B.; de Jonge, M. D.; Ioppolo, J. A.; Harris. H. H.; Rendina, L. M. “High Mitochondrial Accumulation of New Gadolinium(III) Agents Within Tumour Cells”, Chem. Commun., 2014, 50, 2252-2254. [Selected as a front cover highlight] ]

66. Ioppolo, J. A.; Bhadbhade, M.; Fox, M. A.; Rendina, L. M. “Remarkable Cage Deboronation and Rearrangement of a Closo-1,12-dicarbadodecaborane to Form a Neutral Nido-7,9-dicarbaundecaborane”, Chem. Commun., 2013, 49, 3312-3314.

65. Ching, H. Y. V.; Clarke, R. J.; Rendina, L. M. “Supramolecular β-Cyclodextrin Adducts of Boron-Rich DNA Metallointercalators Containing Dicarba-closododecaborane( 12)”, Inorg. Chem., 2013, 52, 10356-10367.

64. Kahlert, J.; Austin, C. J. D.; Kassiou, M.; Rendina, L. M. “The Fifth Element in Drug Design: Boron in Medicinal Chemistry”, Aust. J. Chem. 2013, 66, 1118-1123. [Invited article]

63. Austin, C. J. D.; Kahlert, J.; Kassiou, M.; Rendina, L. M. “The Translocator Protein (TSPO): A Novel Target for Cancer Chemotherapy”, Int. J. Biochem. Cell Biol., 2013, 45, 1212-1216.

62. Sheridan, E. J.; Austin, C. J. D.; Aitken, J. B.; Vogt, S.; Jolliffe, K. A.; Harris, H. H.; Rendina, L. M. “Synchrotron XRF Studies of a Bromine-Labelled Cyclic RGD Peptide Interacting with Individual Tumor Cells”, J. Synchrotron Rad., 2013, 20, 226- 233.

61. Issa F.; Ioppolo J.A.; Rendina L.M. Boron and Gadolinium Neutron Capture Therapy. In: Reedijk, J.; Poeppelmeier, K. eds. Comprehensive Inorganic Chemistry II, Vol 3. Oxford: Elsevier; 2013, pp. 877-900. [Invited article]

60. Ching, H. Y. V.; Clifford, S.; Bahdbhade, M.; Clarke, R. J.; Rendina, L. M. “Synthesis and Supramolecular Studies of Chiral Boronated Platinum(II) Complexes: Insights into the Molecular Recognition of Carboranes by β-Cyclodextrin”, Chem. Eur. J., 2012, 18, 14413–14425.

59. Bannister, S. D.; Rendina, L. M; Kassiou, M. “7-azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands”, Bioorg. Med. Chem. Letters, 2012, 22, 4059–4063.

58. Ching, H. Y. V.; Buck, D. P.; Bahdbhade, M.; Collins, J. G.; Rendina, L. M. “A Ternary Supramolecular System Containing a Boronated DNA-Metallointercalator, β- Cyclodextrin and the Hexanucleotide d(GTCGAC)2”, Chem. Commun., 2012, 48, 880- 882.

57. Crossley, E. L.; Issa, F.; Scarf, A. M.; Kassiou, M.; Rendina, L. M. “Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: Exploitation of the translocator protein for the efficient delivery of boron into human glioma cells”, Chem. Commun., 2011, 47, 12179–12181.

56. Bloch, W. M.; Derwent-Smith, S.; Issa, F.; Morris, J. C.; Rendina, L. M.; Sumby, C. J. “Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures and properties”, Tetrahedron, 2011, 67, 9368–9375.

55. Issa, F.; Kassiou, M.; Rendina, L. M. “Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds”, Chem. Rev., 2011, 111, 5701–5722.

54. Crossley, E. L.; Aitken, J. B.; Vogt, S.; Harris, H. H.; Rendina, L. M. “Uptake and Distribution of a Platinum(II)-Carborane Complex Within a Tumour Cell Using Synchrotron XRF Imaging”, Aust. J. Chem., 2011, 64, 253-257. [Invited article].

53. Hosseini, S. S.; Bhadbhade, M.; Clarke, R. J.; Rutledge, P. J.; Rendina, L. M. “Synthesis, Carbohydrate- and DNA-Binding Studies of Cationic 2,2':6',2''- Terpyridineplatinum(II) Complexes Containing N- and S-donor Boronic Acid Ligands”, Dalton Trans., 2011, 40, 506–513.

52. Crossley, E.L.; Ching, H. Y. V.; Ioppolo, J. A.; Rendina, L. M. "Boron and Gadolinium in the Neutron Capture Therapy of Cancer" in Bioinorganic Medicinal Chemistry, Wiley-VCH, 2011, Alessio, E. ed., pp. 283–305. [Invited article].

51. Rendina, L. M. “Can Lithium Salts Herald a New Era for Neutron Capture Therapy?”, J. Med. Chem., 2010, 53, 8224–8227.

50. Schilter, S.; Urathamakul, T.; Beck, J. L.; Harding, M. M.; Rendina, L. M. “ESI-MS and Thermal Melting Studies of Nanoscale Platinum(II) Metallomacrocycles with DNA”, Dalton Trans., 2010, 39, 11263–11271.

49. Morrison, D. E.; Issa, F.; Bhadbhade, M.; Gröebler, L.; Witting, P. K.; Kassiou, M.; Rutledge, P. J.; Rendina, L. M. “Boronated Phosphonium Salts Containing Arylboronic Acid, Closo- or Nido-Carborane: Synthesis, X-ray Diffraction, In Vitro Cytotoxicity and Cellular Uptake”, J. Biol. Inorg. Chem., 2010, 15, 1305–1318.

48. Crossley, E. L.; Aitken, J. B.; Vogt, S.; Harris, H. H.; Rendina, L. M. “Selective Aggregation of a Pt-Gd Complex Within a Tumor Cell Nucleus”, Angew. Chem., Int. Ed., 2010, 49, 1231–1233.

47. Schilter, D.; Clegg, J. K.; Harding, M. M.; Rendina, L. M. “Platinum(II) and Palladium(II) Metallomacrocycles Derived from Cationic 4,4’-Bipyridinium, 3- Aminopyrazinium and 2-Aminopyrimidinium Ligands”, Dalton Trans., 2010, 39, 239– 247.

46. Ioppolo, J. A.; Kassiou, M.; Rendina, L. M. “Water-Soluble Phosphonium Salts Containing 1,12-Dicarba-closo-dodecaborane(12)”, Tetrahedron Lett., 2009, 50, 6457–6461.

45. Ioppolo, J. A.; Clegg, J. K.; Rendina, L. M. “[1,2-Bis(diphenylphosphino)-1,2- dicarba-closo-dodecaborane-k2P,P’][7,8-Bis(diphenylphosphino)-7,8-dicarba-nidoundecaborato- k2P,P’]gold(I)–dichloromethane–water (2/1/1)”, Acta Cryst., 2009, E65, m603–604.

44. Crisp, M. G.; Rendina, L. M. “Dinuclear Organoplatinum(II) Complexes Containing N-methylbenzamide”, Can. J. Chem., 2009, 87, 212–216 [Invited article].

43. Ioppolo, J. A.; Kepert, C. J.; Price, D. J.; Rendina, L. M. “Mono- and Di-nuclear Gold(I) Complexes Containing 1,12-Dicarba-closo-dodecaborane(12)”, Aust. J. Chem., 2007, 60, 816–820 [Selected as a front cover highlight].

42. Ching, H. Y. V.; Clegg, J. K.; Rendina, L. M. “Synthesis and Preliminary DNABinding Studies of Diimineplatinum(II) Complexes Containing 3- or 4- Pyridineboronic Acid”, Dalton Trans., 2007, 2121–2126.

41. Ioppolo, J. A.; Clegg, J. K.; Rendina, L. M. “Dicarba-closo-dodecaborane(12) Derivatives of Phosphonium Salts: Easy Formation of Nido-Carborane Phosphonium Zwitterions”, Dalton Trans., 2007, 1982–1985 [Selected as a front cover highlight].

40. Crossley, E. L.; Ziolkowski, E. J.; Coderre, J. A.; Rendina, L. M. “Boronated DNABinding Compounds as Potential Agents for Boron Neutron Capture Therapy”, Mini Rev. Med. Chem., 2007, 7, 303 – 313.

39. Lee, C. K. Y.; Groneman, J. L.; Turner, P.; Rendina, L. M.; Harding, M. M. “Synthesis and X-Ray Crystallographic Analysis of Chiral Pyridyl Substituted Carbocyclic Molecular Clefts”, Tetrahedron, 2006, 62, 4870 – 4878.

38. Ziolkowski, E. J.; Turner, P.; Rendina, L. M. “Mono- and Di-nuclear Platinum(II) Complexes Containing O- and N-Bonded Acetamide”, Inorg. Chem. Commun., 2006, 9, 53 – 56.

37. Crossley, E. L.; Caiazza, D.; Rendina, L. M. “A Highly Water-Soluble Platinum(II) Complex Containing a Thiopropyl-1,2-dicarba-closo-dodecaborane(12) Ligand Functionalised with a Pendant Glycerol Group”, Dalton Trans., 2005, 2825 – 2826. [Selected as a “Hot Article” and front cover highlight].

36. Woodhouse, S. L.; Ziolkowski, E. J.; Rendina, L. M. “Synthesis and Anti-Cancer Activity of Dinuclear Platinum(II) Complexes Containing Bis(thioalkyl)dicarba-closododecaborane( 12) Ligands”, Dalton Trans., 2005, 2827 – 2829. [Selected for inclusion in the Royal Society of Chemistry’s “Chemical Biology Virtual Journal”].

35. Todd, J. A.; Turner, P.; Ziolkowski, E. J.; Rendina, L. M. “2,2’:6’,2”- Terpyridineplatinum(II) Complexes Containing Thioalkyl-dicarba-closododecaborane( 12) Ligands”, Inorg. Chem., 2005, 44, 6401 – 6408.

34. Woodhouse, S. L.; Rendina, L. M. “Multinuclear Platinum(II)-Amine Complexes Containing Bis(aminopropyl)-dicarba-closo-dodecaborane(12) Ligands”, Dalton Trans., 2004, 3669 – 3677.

33. Gallasch, D. P.; Woodhouse, S. L.; Rendina, L. M. “Synthesis and Redistribution Reactions of Asymmetric σ−Arylplatinum(II) Complexes Containing 4,7- Phenanthroline”, J. Organomet. Chem., 2004, 689, 1288 – 1294.

32. Todd, J. A.; Rendina, L. M. “The First Examples of Platinum(II)-Amine Complexes Containing 1,2-Dicarba-closo-dodecaborane(12)”, Inorg. Chem. Commun., 2004, 7, 289 – 291.

31. Rendina, L. M.; Hambley, T. W. "Platinum" in Comprehensive Coordination Chemistry II, Volume 6, Fenton, D. E. (Ed.); Elsevier/Pergamon Press: 2004, 673 – 745.

30. Todd, J. A.; Caiazza, D.; Tiekink, E. R. T.; Rendina, L. M. “Synthesis of Diimineplatinum(II) Complexes Containing the 1,2-Dicarba-closo-dodecaborane(12)- 1-thiolato Ligand”, Inorg. Chim. Acta, 2003, 352, 208 – 212.

29. Wenger, E.; Rendina, L. “Protagonists in chemistry”, Inorg. Chim. Acta , 2003, 352, 1 – 3.

28. Crisp, M. G.; Tiekink, E. R. T.; Rendina, L. M. “Cationic σ−Phenylplatinum(II) Complexes with Carboxylic Acid Functionality: pKa Determinations and X-ray Structures”, Inorg. Chem., 2003, 42, 1057 – 1063.

27. Todd, J. A.; Rendina, L. M. “Synthesis and DNA-Binding Properties of Cationic 2,2’:6’,2”-Terpyridineplatinum(II) Complexes Containing 1,2- and 1,7-Dicarbacloso- dodecaborane(12)”, Inorg. Chem., 2002, 41, 3331 – 3333.

26. Janzen, M. C.; Jenkins, H. A.; Jennings, M. C.; Rendina, L. M.; Puddephatt, R. J. “Ring Expansion and Contraction in Reactions of an Alkyne with Stannylplatinum(IV) Metallacycles: Formation of an Alkyl(alkenyl)(alkynyl)platinum(IV) Complex”, Organometallics, 2002, 21, 1257 – 1261.

25. Woodhouse, S. L.; Rendina, L. M. “Synthesis and DNA-Binding Properties of Dinuclear Platinum(II)-Amine Complexes of 1,7-Dicarba-closo-dodecaborane(12)”, Chem. Commun., 2001, 2464 – 2465.

24. Gallasch, D. P.; Tiekink, E. R. T.; Rendina, L. M. “A New Methodology for the Preparation of Cationic Organoplatinum(II) Complexes with Hydrogen-Bonding Functionality”, Organometallics, 2001, 20, 3373 – 3382.

23. Crisp, M. G.; Rendina, L. M.; Tiekink, E. R. T. “Crystal Structure of transbis( diethylhydroxyphosphine)diethylphosphinito(iodo)platinum(II) triethylphosphine oxide solvate (1:1), [(Et2(OH)P)2(Et2PO)IPt].Et3PO”, Z. Kristallog. NCS, 2001, 216, 243 – 244.

22. Crisp, M. G.; Rendina, L. M.; Tiekink, E. R. T. “Refinement of the Crystal Structure of Trans-chlorophenylbis(triphenylphosphine)platinum(II) at 173 K, C42H35ClP2Pt”, Z. Kristallog. NCS, 2001, 216, 249 – 250.

21. Gianneschi, N. C.; Tiekink, E. R. T.; Rendina, L. M. “Dinuclear Platinum Complexes with Hydrogen Bonding Functionality: Noncovalent Assembly of Nanoscale Cyclic Arrays”, J. Am. Chem. Soc., 2000, 122, 8474 – 8479.

20. Crisp, M. G.; Pyke, S. M.; Rendina, L. M. “Dinuclear Organoplatinum(II)- Methyldiphenylphosphine Complexes of Nicotinic Acid”, J. Organomet. Chem., 2000, 607, 222 – 226.

19. Rendina, L. M.; Tiekink, E. R. T.; Todd, J. A. “Crystal Structure of 1- (Phthalimidoethyl)-1,2-dicarba-closo-dodecaborane”, Z. Kristallog. NCS, 2000, 215, 547 – 548.

18. Rendina, L. M.; Tiekink, E. R. T.; Todd, J. A. “Crystal Structure of 1- (Phthalimidomethyl)-1,2-dicarba-closo-dodecaborane”, Z. Kristallog. NCS, 2000, 215, 259 – 260.

17. Janzen, M. C.; Jenkins, H. A.; Jennings, M. C.; Rendina, L. M.; Puddephatt, R. J. “Easy Ring Expansion and Contraction in Pt–Sn Bonded Metallacycles”, J. Chem. Soc., Dalton Trans., 1999, 1713 – 1715.

16. Janzen, M. C.; Jenkins, H. A.; Rendina, L. M.; Vittal, J. J.; Puddephatt, R. J. “Synthesis of Metallacycles by Oxidative Addition of Sn-S, Sn-Se and Ge-Te Containing Precursors to Platinum(II)”, Inorg. Chem., 1999, 38, 2123 – 2130.

15. Rendina, L. M.; Hill, G. S.; Irwin, M. J.; Levy, C. J.; Puddephatt, R. J. “Platinum(II) Complexes of Dimethyl Sulfide”, Inorg. Synth., 1998, 33, 149 – 153.

14. Clark, A. D.; Rendina, L. M.; Tiekink, E. R. T. “Crystal Structure of Di-4- pyridylmethanone, C11H8N2O”, Z. Krist., 1998, 213, 382.

13. Paul, R. L.; Gheller, S. F.; Heath, G. A.; Hockless, D. C. R.; Rendina, L. M.; Sterns, M. “Co-existing Pseudo-planar and Saddle Conformers of Tetramethyltetra-aza-[14]- annulene Platinum Complexes: X-Ray Crystallographic Studies on [PtII(tmtaa)] and trans-[PtIVCl2(tmtaa)]”, J. Chem. Soc., Dalton Trans., 1997, 4143 – 4145.

12. Rendina, L. M.; Puddephatt, R. J. “Oxidative Addition Reactions of Organoplatinum(II) Complexes with Nitrogen-Donor Ligands”, Chem. Rev., 1997, 97, 1735 – 1754.

11. Hill, G. S.; Rendina, L. M.; Puddephatt, R. J. “Cationic Platinum(II) Complexes: Platinum–Alkyl Bond Cleavage by a Powerful Lewis Acid.”, J. Chem. Soc., Dalton Trans., 1996, 1809 – 1813.

10. Irwin, M. J.; Rendina, L. M.; Vittal, J. J.; Puddephatt, R. J. “A Strategy for Synthesis of Large Gold Rings”, J. Chem. Soc., Chem. Commun., 1996, 1281 – 1282.

9. Rendina, L. M.; Vittal, J. J.; Puddephatt, R. J. “Luminescent Platinum-Tin Bonded Metallacycles: First Oxidative Addition of Sn–S Bonds.”, Organometallics, 1996, 15, 1749 – 1751.

8. Hill, G. S.; Rendina, L. M.; Puddephatt, R. J. “Alkyl(hydrido)platinum(IV) Complexes: The Mechanism of Pt–C Bond Protonolysis.”, Organometallics, 1995, 14, 4966 – 4968.

7. Rendina, L. M.; Vittal, J. J.; Puddephatt, R. J. “Stable Organoplatinum(IV) Complexes with Pendant Free-Radicals.”, Organometallics, 1995, 14, 2188 – 2193.

6. Rendina, L. M.; Vittal, J. J.; Puddephatt, R. J. “Cationic Carbene Complexes of Platinum(IV): Structure of a Secondary Carbene Complex.”, Organometallics, 1995, 14, 1030 – 1038.

5. Bennett, M. A.; Jin, H.; Li, S.; Rendina, L. M.; Willis, A. C. “Cis- Hydroxyplatination of Dimethyl Maleate: Modeling the Intermediates in a Catalytic Alkene-Hydration Cycle with Organoplatinum(II)-Hydroxo Complexes.”, J. Am. Chem. Soc., 1995, 117, 8335 – 8340.

4. Bennett, M. A.; Canty, A. J.; Felixberger, J. K.; Rendina, L. M.; Sunderland, C.; Willis, A. C. “Organoplatinum(II) and -(IV) and Organopalladium(II) and -(IV) Complexes of a Macrocyclic Thioether: X-ray Crystal Structure of Pt(C6H5)2(9S3), an Example of Exodentate 1,4,7-Trithiacyclononane (9S3).”, Inorg. Chem., 1993, 32, 1951 – 1958.

3. Broomhead, J. A.; Rendina, L. M.; Webster, L. K. “Dinuclear Complexes of Platinum Having Anticancer Properties. DNA-Binding Studies and Biological Activity of Bis(4,4'-dipyrazolylmethane-N,N')bis[dichloroplatinum(II)] and Related Complexes.”, J. Inorg. Biochem., 1993, 49, 221 – 234.

2. Broomhead, J. A.; Rendina, L. M.; Sterns, M. “Dinuclear Complexes of Platinum with the 4,4'-Dipyrazolylmethane Ligand. Synthesis, Characterisation, and X-ray Crystal Structure of γ-Bis(4,4'-dipyrazolylmethane-N,N')bis[dichloroplatinum(II)] — N,N-Dimethylformamide (1/2) and Related Complexes.”, Inorg. Chem., 1992, 31, 1880 – 1889.

1. Broomhead, J. A.; Rendina, L. M.; Camm, G.; Sterns, M. "Platinum and Other Dinuclear Metal Complexes of 4,4'-Dipyrazolylmethane Showing Activity Against P388 Murine Leukemia.", Anticancer Drug Res., 1991, 6, 213.