Institute Director

M. Frederick Hawthorne was born in Fort Scott, Kansas and he received his elementary and secondary education in Kansas and Missouri. Prior to high school graduation, through examination he entered the Missouri School of Mines and Metallurgy, Rolla, Missouri as a chemical engineering student. He then transferred to Pomona College, Claremont, California and received a B.A. degree in chemistry. Hawthorne immediately commenced graduate work in organic chemistry at the University of California, Los Angeles, where he received his Ph.D. Iowa State University, Ames, Iowa then attracted Hawthorne as a postdoctoral associate (physical-organic chemistry) for a period of sixteen months. He joined the Rohm and Haas Company, Redstone Arsenal Research Division, Huntsville, Alabama as a Senior Research Chemist. Hawthorne launched his career in borane cluster chemistry by organizing and leading the Organometallic Chemistry Group at Rohm and Haas, Redstone. While on leave of absence from Rohm and Haas he served as a Visiting Lecturer in physical-organic chemistry at Harvard University, Cambridge, Massachusetts. Hawthorne served as a Laboratory Head at the Rohm and Haas Co., Philadelphia, Pennsylvania and in 1962, he became a full Professor at the University of California, Riverside. He transferred to the Los Angeles campus in 1969. In 1998 he was appointed University Professor of Chemistry, the most distinguished title bestowed upon faculty by the Regents of the University of California. Hawthorne joins twenty colleagues sharing this title University-wide.  In 2006 Hawthorne retired from UCLA and founded the International Institute of Nano and Molecular Medicine at the University of Missouri, where he is Institute Director and Curators’ Distinguished Professor of Chemistry and Radiology.

Hawthorne is the author or co-author of more than 530 research papers, 30 patents and 10 book chapters that reflect the joint efforts of approximately 200 Ph.D. students and postdoctoral associates and 11 Ph.D. coworkers at Rohm and Haas, Redstone. His students and postdoctoral associates represent 21 different countries and 35 of them now occupy academic positions. One of them was a space shuttle astronaut; Anna Lee Fisher (née Sims), M.S. (chemistry), M.D.

Awards

1963 Alfred P. Sloan Research Fellowship
1968 Chancellor's Award for Research at the University of California, Riverside.
1972 UCLA McCoy Award for Contributions to Chemistry
1973 The American Chemical Society Award in Inorganic Chemistry
1974 Honorary Sc.D. degree - Pomona College, California
1986 U. S. Air Force Meritorious Civilian Service Medal
1986 Richard C. Tolman Medal Award of the Southern California Section of the American Chemical Society
1986 Fellow of the Japan Society for the Promotion of Science
1988 First recipient of the Boron USA Award for Distinguished Achievements in Boron Chemistry
1988 American Chemical Society Award for Distinguished Service in the Advancement of Inorganic Chemistry.
1990 Alexander von Humboldt Foundation Award for Senior U.S. Scientists.
1990 Distinguished Visiting Professor - Ohio State University
1991 Bailar Medal for Achievement in Inorganic Chemistry
1992 Ph.D., honoris causa, by Uppsala University, Uppsala, Sweden
1993 Polyhedron Medal and Prize for Creativity in Inorganic and Organometallic Chemistry.
1994 Chemical Pioneer Award of the American Institute of Chemists
1994 Recipient of the Willard Gibbs Medal presented by the Chicago Section of the American Chemical Society.
1996 Polyhedral Borane Chemistry Award - IMEBORON International Committee on Boron Chemistry
1997 U.S. National Academy of Sciences Award in Chemical Sciences
1997 Seaborg Medal - UCLA Association of Chemists and Biochemists
1998 Centenary Lectureship - The Royal Society of Chemistry
2001 Basolo Medal of the Chicago Section of the American Chemical Society
2003 Co-winner of the King Faisal International Prize for Science
2003 Monie A. Ferst Award - Georgia Institute of Technology Chapter of Sigma Xi Society
2009 Priestley Medal - The American Chemical Society
2009 Fellow of the American Chemical Society
2009 Honored with the Missouri State Senate’s Resolution of Appreciation for Scientific Achievements.
2010 Curators’ Distinguished Professor at the University of Missouri
2011 UCLA established the annual M. Frederick Hawthorne Lecture, with Hawthorne delivering the inaugural lecture.

2013 Recipient of the National Medal of Science, the highest honor bestowed by the country to scientists.

Membership

1973 U.S. National Academy of Sciences
1975 American Academy of Arts and Sciences
1976 Cosmos Club, Washington, D.C.
1980 American Association for the Advancement of Science
1995 Göttingen Academy of Sciences


Advisory Positions

National Research Council - U.S. National Academy of Sciences - Member of the Review Panel on U.S.-Soviet Scientific Exchange (National Academy of Sciences) and a co-author of the Kaysen Panel Report (Chemistry Section), 1975-76; Chemistry Member of the Board on International Scientific Exchange (National Academy of Sciences), 1975-78; National Academy of Sciences Board of Army Science and Technology and under these auspices chaired an oversight panel concerned with the conduct of Chemical Defense Research at the U. S. Army Chemical Research, Development and Engineering Center during 1985-89.

Department of Defense - U.S. Air Force Scientific Advisory Board, Office of the Secretary of the Air Force, 1980-86; Consultant to the Defense Science Board Task Force Study on the Detection and Neutralization of Illegal Drugs and Terrorist Devices, 1987-88; Member of the Board of Army Science and Technology for the U.S. National Academies of Science, 2005-10; Chemical Demilitarization Committee, 2009-present.

Department of Energy - Director's External Advisory Board, The Los Alamos National Laboratory, 1991-92; Member of the Executive Committee of the International Society for Neutron Capture Therapy, 1992-98; President of International Society for Neutron Capture Therapy, 1996-98; Member of the Environmental and Energy Sciences Division Review Committee of the Idaho National Engineering and Environmental Laboratory, 2001.


Editorialship

Inorganic Chemistry  - Associate Editor 1966-69; Editor-in-Chief 1969-2001
Bioconjugate Chemistry - Editorial Advisory Board


Fred Hawthorne

Publications

2011 539 Satish S. Jalisatgi, Vikas S.Kulkarni, Betty Tang, Zachary H. Houston, Mark W. Lee, Jr. and M. Frederick Hawthorne “A Convenient Route to Diversely Substituted Icosahedral Closomer Nanoscaffolds.” Journal of the American Chemical Society, 133, 12382-12385 (2011).
  538 Oleg Bondarev and M. Frederick Hawthorne “Catalytic Hydroxylation of [Closo-B(12)H(12)](2-)-Adaptation of the Periana Reaction to a Polyhedral Borane.” Chemical Communications, 47, 6978 – 6980 (2011).
  537 Lalit N. Goswami, Shatadru Chakravarty, Mark W. Lee, Jr., Satish S. Jalisatgi and M. Frederick Hawthorne “Extensions of the Icosahedral Closomer Structure by Using Azide-Alkyne Click Reactions.” Angewandte Chemie International Edition in English, 50, 4689-4691 (2011).
  536 Alexander V. Safronov, Satish S. Jalisatgi, Han Baek Lee, and M. Frederick Hawthorne.  “Chemical Hydrogen Storage Using Polynuclear Borane Anion Salts”, Int. J. Hydrogen Energ., 36, 234-239 (2011).
  535 A. V. Safronov, M. F. Hawthorne. “Novel Synthesis of 3-iodo-ortho-carborane”, Inorg. Chim. Acta (2011), doi:10.1016/j.ica.2011.05.002.
2010 534 M. Frederick Hawthorne. “Advances at the Interface of Polyhedral Borane Chemistry and Medicine”, Comments on Inorganic Chemistry, 31: 3, 153 – 163 (2010).
  533 Yulia Sevryugina, Richard L. Julius, and M. Frederick Hawthorne, “Novel Approach to Aminocarboranes by Mild Amidation of Selected Iodo-carboranes”, Inorg. Chem., 49, 10627-10634 (2010).
  532 Steven D. Karlen, Horacio Reyes, R.E. Taylor, Saeed I. Khan, M. Frederick Hawthorne, and Miguel A. Garcia-Garibay.  “Symmetry and Dynamics of Molecular Rotors in Amphidynamic Molecular Crystals”, Proc. Natl. Acad. Sci. USA, 107, 14973 (2010).
2009 531 John D. Brockman, David .W. Nigg, M. Frederick Hawthorne, Mark W. Lee and Charles McKibben.  "Characterization of a boron neutron capture therapy beam line at the University of Missouri Research Reactor", J. Radioanal. Nucl. Chem., 282, 157-160 (2009).
  530 M. Frederick Hawthorne. “Boron, My Favorite Element”, J. Chem. Educ., 86(10), 1131 (2009).
  529 Robert D. Kennedy, Carolyn B. Knobler, and M. Frederick Hawthorne.  “Towards Unidirectional Rotary Motion in Nickelacarboranes: Characterization of Diastereomeric Nickel Bis(Dicarbollide) Complexes Derived from the [Nido-7-CH3-7,8-C2B9H11]– Anion”, Inorganic Chemistry, 48, 9377-9384 (2009).
  528 John D. Brockman, David .W. Nigg, M. Frederick Hawthorne, and Charles McKibben.  “Spectral performance of a composite single-crystal filtered thermal neutron beam for BNCT research at the University of Missouri”, Appl. Radiat. Isot., 67, 222-225 (2009).
2008 527 John D. Brockman, David. W. Nigg, M. Frederick Hawthorne, and Charles. McKibben.  “A new single-crystal filtered thermal neutron beam for BNCT research at the University of Missouri”, Proceedings from the International Conference on Reactor Physics, Nuclear Power: A Sustainable Resource, Casino-Kursaal Conference Center, Interlaken, Switzerland, (2008).
  526 R. L. Julius, & M. F. Hawthorne. “Amyloid Disease Prevention by Transthyretin Native State Complexation with Caroborane Derivatives Lacking Cyclooxygenase Inhibition”, Drug News and Perspectives, 21, 258 (2008).
  525 Michael F. Z. Page, Satish S. Jalisatgi, Andreas Maderna and M. Frederick Hawthorne, “Design and Synthesis of a Candidate α-Human Thrombin Irreversible Inhibitor Containing a Hydrophobic Carborane Pharmacophore”, Synthesis, No. 4, 555-563 (2008).
2007 524 D. Scott Wilbur, Ming-Kuan Chyan, Donald K. Hamlin, Robert L. Vesslla, Timothy J. Wedge, and M. Frederick Hawthorne. “Reagents for Astatination of Biomolecules. 2. Conjunction of Anionic Boron Cage Pendant Groups to a Protein Provides a Method for Direct Labeling that is Stable to in Vivo Deastatination”, Bioconjugate Chem., 18, 1126-1240 (2007).
  523 Omar K. Farha, Alexander M. Spokoyny, M. Frederick Hawthorne, Karen L. Mulfort, Chad A. Mirkin and Joseph T. Hupp, “Synthesis and Hydrogen Sorption of Carborane-based Met-organic Framework Materials”, J. Am. Chem. Soc., 129(42), 12680-12681 (2007).
  522 Zhu Yinghuai, Effendi Widaja, Shirley Lo Pei Sia, Wang Zhan, Keith Carpenter, John A. Maguire, Narayan S. Hosmane, and M. Frederick Hawthorne, “Ruthenium(0) Nanoparticle-Catalyzed Isotope Exchange between 10B and 11B Nuclei in Decaborane(14)”, J. Am. Chem. Soc. 129, 6507 (2007).
  521 Bradley W. Schuller, Arlin B. Rogers, Kathleen S. Cormier, Kent J. Riley, Peter J. Beinns,Richard Julius, M. Frederick Hawthorne, and Jeffrey A. Coderre, “No Significant Endothelial Apoptosis in the Radiation-Induced Gastrointestinal Syndrome”, Int. J. Radiation Oncology Biol. Phys., 68, 205 (2007).
  520 Richard L. Julius, Omar K. Farha, Janet Chiang, L. Jeanne Perry, and M. Frederick Hawthorne,“Synthesis and Evaluation of Transthyretin Amyloidosis Inhibitors Containing Carborane Pharmacophores”, Proc. Natl. Acad. Sci. USA, 104, 4808 (2007).
  519 Mark W. Lee, Omar K. Farha, M. Frederick Hawthorne, and Corwin H. Hansch, “Alkoxy Derivatives of Dodecaborate: Discrete Nanomolecular Ions with Tunable Pseudometallic Properties”, Angew. Chem. Int. Ed., 46, 3018 (2007).
2006 518 M. Frederick Hawthorne, Bhaskar M. Ramachandran, Robert D. Kennedy, Carolyn B. Knobler, “Approaches to Rotary Molecular Motors”, Proceedings of the Twelfth International Meeting on Boron Chemistry (IMEBORON XII), Pure Appl. Chem., 78, 1299-1304 (2006).
2005 517 Bradley W. Schuller. Peter J. Binns. Kent J. Riley, Ling Ma, Frederick Hawthorne, and Jeffrey A. Coderre, “ Selective Irradiation of the Vascular Endothelium Has No Effect on the Survival of Murine Intestinal Crypt Stem Cells”, Proc. Nat. Acad. Sci. 103 (10), 3787-3792 (2005).
  516 Omar K. Farha, Richard L. Julius, M. Frederick Hawthorne, “Synthesis of a Homotrifunctional Conjugation Reagent Based on Maleimide Chemistry”, Tetrahedron Letters, 47, 2619-2622 (2005).
  515 Tiejun Li, Julie Hamdi, and M. Frederick Hawthorne, “Unilamellar Liposomes with Enhanced Boron Content”, Bioconj. Chem., 17, 15-20 (2005).
514 Bhaskar M. Ramachandran and M. Frederick Hawthorne, "Synthesis and Structural Characterization of Symmetrical Closo-4,7-I 2-1,2-C2B10H10 and [(CH3)3NH][nido-2,4-I 2-7,8-C2B9H10]", Inorg. Chem., 45, 336-340 (2005).
  513 Tiejun Li, Satish S. Jalisatgi, Michael J. Bayer, Andreas Maderna, Saeed I. Khan, and M. Frederick Hawthorne, “Organic Syntheses on an Icosahedral Borane Surface: Closomer Structures with Twelvefold Functionality”, J. Am. Chem. Soc., 127, 17832-17841 (2005).
  512 Ling Ma, Julie Hamdi, Frances Wong, and M. Frederick Hawthorne, “Closomers of High Boron Content: Synthesis, Characterization, and Potential Application as Unimolecular Nanoparticle Delivery Vehicles for BNCT”, Inorg. Chem.,45, 278-285 (2005).
  511 Omar K. Farha, Richard L. Julius, Mark W. Lee, Ramon E. Huertas, Carolyn B. Knobler, and M. Frederick Hawthorne, “Synthesis of Stable Dodeca-(alkoxy) Derivatives of Hypercloso-B12H12”, J. Am. Chem. Soc., 127(51), 18243-18251 (2005).
  510 Bhaskar M. Ramachandran, Carolyn B. Knobler, and M. Frederick Hawthorne, “Example of an Intramolecular, Non-classical C-H--pHydrogen Bonding Interaction in an Arylcarborane Derivative”, J. Mol. Struct. (2005).
  509 Ling Ma, Julie Hamdi, Jiaxing Huang, and M. Frederick Hawthorne, “Camouflaged Carborane Amphiphiles: Synthesis and Self-assembly”, Inorg. Chem., 44, 7249-7258 (2005).
  508 Hershel Jude, Hendrik Disteldorf, Sonja Fischer, Timothy J. Wedge, Adam M. Hawkridge, Atta M. Arif, M. Frederick Hawthorne, David C. Muddiman, and Peter J. Stang, “Coordination Driven Self-assemblies with a Carborane Backbone”, J. Am. Chem. Soc., 127, 12131-12139 (2005).
507

Axel Herzog, Satish S. Jalisatgi, Carolyn B. Knobler, Timothy J. Wedge, and M. Frederick Hawthorne, “Camouflaged Carborarods Derived from B-permethyl-1,12-diethynyl-para-and B-octamethyl-1,7-diethynyl-meta-carborane Modules”, Chem. Eur. J11, 7155-7174 (2005).

2004 506

Michael J. Bayer, Satish S. Jalisatgi, Brian Smart, Axel Herzog, Carolyn B. Knobler, and M. Frederick Hawthorne, “B-Octamethyl-[12]Mercuracarborand–4 as Host for “Naked” Fluoride Ions”, Angew. Chem. Int. Ed.116, 1890-1893 (2004)

505

D. Scott Wilbur, Ming-Kuan Chyan, Donald K. Hamlin, Brian B. Kegley, Ruedi Risler, Pradip M. Pathare, Janna Quinn, Robert L. Vessella, Catherine Foulon, Michael Zalutsky, Timothy J. Wedge, and M. Frederick Hawthorne, “Reagents for Astatination of Biomolecules. Comparison of the In Vivo Distribution and Stability of Some Radioiodinated and Astatinated Benzamidyl- and nido-Carboranyl Compounds”, Bioconj. Chem., 15, 203-223 (2004).

504

M. Frederick Hawthorne, Jeffrey I. Zink, Johnny M. Skelton, Michael J. Bayer, Chris Liu, Ester Livshits, Roi Baer, and Daniel Neuhauser, “Electrical or Photocontrol of the Rotary Motion of a Metallacarborane”, Science303, 1849-1851 (2004). [pdf]

 

503

Timothy J. Wedge, Axel Herzog, Ramón Huertas, Mark W. Lee, Carolyn B. Knobler and M. Frederick Hawthorne, “Metal-Metal Communication Through Carborane Cages Supporting Electroactive [h5-CpFe(CO)2] Substituents”, Organometallics, 23, 482 (2004).

 

502

Michael J. Bayer and M. Frederick Hawthorne, “An Improved Method for the Synthesis of [Closo-B12(OH)12]2-,” Inorg. Chem., 43, 2018-2020 (2004).

 2003

502

Tiejun Li, Jason Thomas, and M. Frederick Hawthorne, “Liposomes from Novel Carborane-containing Lipids for Boron Neutron Capture Therapy”, Abstract of papers, 225 th Annual ACS meeting, March 25, 2003. (2003).

 

501

Sean L. Johnston, Mark W. Lee, and M. Frederick Hawthorne, “Development of Cell-surface Protein Targeted CT and MR Contrast Agents”, Applied Radiology (Supplement), 70-77 (2003).

500

M. Frederick Hawthorne, “New Discoveries at the Interface of Boron and Carbon Chemistries,” Pure Appl. Chem.75, 1157 (2003).[pdf]

 

499

M. Frederick Hawthorne, “Some Biomedical Applications of Aromatic Polyhedral Boranes and Their Progeny,” Special Publication of the King Faisal Foundation Honoring the King Faisal International Prize in Science 2003 (2003).

 

498

M. F Frederick Hawthorne, Satish Jalisatgi, Cynthia L. Beno, David E. Harwell and Carolyn B. Knobler, “Intra and Intermolecular Hydrogen Bonding in Some Cobaltacarboranes”, J. Mol. Struct., 656, 239-247 (2003).

 

497

M. Frederick Hawthorne and Mark W. Lee, “A Critical Assessment of Boron Target Compounds for Boron Neutron Capture Therapy”, J. Neuro-Oncol., 62, 33-45 (2003).

 

496

Yinghuai Zhu, Keith Carpenter, Ching Chi Bun, Stefan Bahnmueller, Chan Pek Ke, Venugopal    Shanmugham Srid, Leong Weng Kee, and M. Frederick Hawthorne, “(R)–Binap-Mediated Asymmetric Hydrogenation Using a Rhodacarborane Catalyst in Ionic Liquid Media,” Angew. Chem. Int. Ed. , 42, 3792 (2003).

 

495

Michael J. Bayer, Axel Herzog, Martin Diaz, George A. Harakas, Hans Lee, Carolyn B. Knobler, and M. Frederick Hawthorne, “The Synthesis of Carboracycles Derived from B,B`-Bis(aryl) Derivatives of Icosahedral ortho-Carborane,” Chem. Eur. J., 9, 2732 (2003). [pdf]

  494 Timothy J. Wedge and M. Frederick Hawthorne, “Multidentate Carborane-Containing Lewis Acids and Their Chemistry:Mercuracarborands,” Coord. Chem. Rev.  240, 111 (2003). [pdf]

2002

493

M. Frederick Hawthorne, “Further Advances at the Interface of Boron and Carbon Chemistries,” Proceedings of the Eleventh International Conference on Boron Chemistry, Published by the A. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Y. N. Bubanov, Editor., Moscow, Russia (2002).

 

492

Andreas Maderna Ramon Huertas, M. Frederick Hawthorne, Raymond Luguya, and M. Graca H. Vicente, “Synthesis of a Porphyrin-labeled Carboranyl Phosphate Diester: A Potential New Drug for Boron Neutron Capture Therapy,” Chem. Comm. 16, 1784(2002).

 

491

M. Frederick Hawthorne, Kenneth Shelly, and Fangbiao Li, “Versatile Chemistry of the [B20H18]2- Ions: Novel Reactions and Structural Motifs,” Chem. Comm., 547(2002).

2001

490

Mark B. Smuckler, Satish S. Jalisatgi, Lufeng Guan, Akira Nakanishi, Harumi Kasamatsu, and M. Frederick Hawthorne, “Boron-RichOligomeric Phosphate Diesters that Target the Cell Nucleus In Vitro,” Frontiers in Neutron Capture Therapy, Vol.2, M. Frederick Hawthorne, Kenneth Shelly and Richard J. Wiersema, Editors.  Kluwer Academic/Plenum Publishers: New York,  New York, 1103(2001).

 

489

Fangbiao Li, Kenneth Shelly, Carolyn B. Knobler and M. Frederick Hawthorne, “Benzoquinone Oxidation of the [ae-B20H17NH3]3- and [ae-B20H17OH]4- Ions,” Frontiers in Neutron Capture Therapy, Vol.2, M. Frederick Hawthorne, Kenneth Shelly, and Richard J.Wiersema, Editors.  Kluwer Academic/Plenum Publishers: New York,  New York, 807 (2001).

 

488

Toralf Peymann, Kenneth Shelly and M. Frederick Hawthorne, “Recent Developments in the Chemistry of [B12H12]2-,” Frontiers in Neutron Capture Therapy, Vol.2, M. Frederick Hawthorne, Kenneth Shelly and Richard J. Wiersema, Editors.  KluwerAcademic/Plenum Publishers: New York, New York, 775 (2001).

  487

Toralf Peymann, Carolyn B. Knobler, Saeed I. Khan and M. Frederick Hawthorne, “Dodecahydroxy-closo-dodecaborate (2-),” J. Am. Chem. Soc. 123, 2182 (2001).

 

486

K.J. Stelzer, P. R. Gavin, R. Risler, H. Kippenes, M. F. Hawthorne, D.W. Nigg and G. E. Laramore, “Boron Neutron Capture-Enhanced Fast Neutron Therapy (BNC/FNT) for Non-Small Cell Lung Cancer in Canine Patients,” Frontiers in Neutron Capture Therapy, Vol.1, M. Frederick Hawthorne, Kenneth Shelly and Richard J. Wiersema, Editors.  Kluwer Academic/Plenum Publishers: New York, New York, 735 (2001).

 

485

Axel Herzog, Carolyn B. Knobler and M. Frederick Hawthorne,  “Synthesis, Structure and Reactivity of closo-2,3,4,5,6,7,8,9,10,11-decahydroxy-1,12-bis-(sulfonicacid)-1,12-dicarbadodecaborane (12),” J. Am. Chem. Soc. 123, 12791 (2001).

 

484

Andreas Maderna, Axel Herzog Carolyn B. Knobler and M. Frederick Hawthorne, “The Syntheses of Amphiphilic CamouflagedCarboranes as Modules for Supramolecular Construction,” J. Am. Chem. Soc123, 10423 (2001).

 

483

M. Frederick Hawthorne, “Obituary:  Donald J. Cram (1919-2001),” Nature 412, 696 (2001).

 

482

George E. Laramore, K.J. Stelzer, R. Risler, J.L. Schwartz, J.J. Douglas, J.P. Einck, D.W. Nigg, C.A. Wemple, J.K. Hartwell, Y.D.Harker, Patrick R. Gavin and M. Frederick Hawthorne,  “Neutron Capture Therapy (NCT) Enhancement of Fast Neutron Radiotherapy:  Application to Non-Small Cell Lung Cancer,” Proceedings of the Sixteenth International Conference on Application of Accelerators in Research and Industry, J.L. Duggan and I.L. Morgan, Editors. American Institute of Physics (2001).

 

481

Jason Thomas and M. Frederick Hawthorne, “Dodeca(carboranyl)-substituted Closomers: Toward Unimolecular Nanoparticles as Delivery Vehicles for BNCT,” Chem. Comm.1884 (2001).

 

480

Theodore W. Bitner, Timothy J. Wedge, M. Frederick Hawthorne and Jeffrey I. Zink, “Synthesis and Luminescence Spetroscopy of a Series of [h5-CpFe(CO)2] Complexes Containing 1,12-Dicarba-closo-dodecaboranyl  and -ylene Ligands,” Inorg. Chem. 40, 5428 (2001).

 

479

Hans Lee, Carolyn B. Knobler and M. Frederick Hawthorne, “A Hydrogen Bonded [(Mercuracarborand-Water)2-Benzene] p-Sandwich Complex,” Angew. Chem. Int. Ed. 40, 3058 (2001).

 

478

Hans Lee, Carolyn B. Knobler and M. Frederick Hawthorne, “Octahedral Coordination of Halide Ions (I-, Br-, Cl-) Sandwich Bonded with Tridentate Mercuracarborand-3 Receptors,” J. Am. Chem. Soc. 123, 8543 (2001).

 

477

Hans Lee, Carolyn B. Knobler and M. Frederick Hawthorne, “Modular Self-Assembly of A Microporous Solid Based upon Mercuracarborand-4 and A New Bonding Motif,” Angew. Chem. Int. Ed. 40, 2124 (2001).

 

476

Axel Herzog, Ryan P. Callahan, Charles L.B. Macdonald, Vincent M. Lynch, M. Frederick Hawthorne and Richard J. Lagow, “APerfluorinated Nanosphere: Synthesis and Structure of Perfluoro-deca-B-methyl-para-carborane,” Angew. Chem. Int. Ed. 40, 2121 (2001).

 

475

Toralf Peymann, Carolyn Knobler, Saeed I. Khan and M. Frederick Hawthorne, “Dodeca(benzyloxy)dodecaborane,B12(OCH2Ph)12: A Stable Derivative of hypercloso-B12H12,” Angew. Chem. Int. Ed. 40, 1664 (2001). [pdf]

 

474

Andreas Maderna, Carolyn Knobler and M. Frederick Hawthorne, “Twelvefold Functionalization of an Icosahedral Surface by TotalEsterification of [B12(OH)12]2-: 12(12)-Closomers,” Angew. Chem. Int. Ed. 40, 1661 (2001). [pdf]

 

473

Toralf Peymann, Carolyn B. Knobler, Saeed I. Khan and M. Frederick Hawthorne, “Dodecamethyl-closo-dodecaborate(2-),” Inorg. Chem. 40, 1291 (2001). [pdf]

2000

472

Hans Lee, Carolyn B. Knobler and M. Frederick Hawthorne, “Supramolecular Self-Assembly Directed by Carborane C-H¼F Interactions,” Chem. Comm24, 2485 (2000).

 

471

Ibrahim H.A. Badr, R. Daniel Johnson, Martin Diaz, M. Frederick Hawthorne and Leonidas G.      Bachas, “A Selective Optical Sensor Based on [9]Mercuracarborand-3, A New Type of Ionopore with a Chloride Complexing Cavity,” Anal. Chem., 72, 4249 (2000).

 

470

Juston J. Rockwell, Axel Herzog, Toralf Peymann, Carolyn B. Knobler and M. Frederick  Hawthorne, “Recent Advances in the Field of Camouflaged Carboranes and Polyhedral Boranes,” Current Sci.78, 405 (2000).

 

469

Hans Lee, Martin Diaz, Carolyn Knobler and M. Frederick Hawthorne, “Octahedral Coordination of Iodide in an ElectrophilicSandwich,” Angew. Chem. Int. Ed.39, 776 (2000).

 

468

Toralf Peymann, Carolyn B. Knobler and M. Frederick Hawthorne, “A Study of the Sequential Acid-Catalyzed Hydroxylation ofDodecahydro-closo-Dodecaborate(2-),” Inorg. Chem., 39, 1163 (2000).

 

467

M. Frederick Hawthorne, “Broadening the Conflux of Boron and Carbon Chemistries,”  Proceedings of the Tenth International Conference on Boron Chemistry, Contemporary Boron Chemistry, Edited by M. Davidson, A.K. Hughes, T.B. Marder and K. Wade, Royal Society of Chemistry:  Cambridge, 197 (2000).

 

466

Weilin Chen, Martin Diaz, Juston Rockwell, Carolyn B. Knobler and M. Frederick Hawthorne,   “Synthesis and Characterization of Water-Soluble Boron-Substituted Ortho-Carborane Derivatives,” Comptes Rendus de l’Académie des Sciences – Série IIc –Chemie3, 223 (2000).

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Hawthorne Research Group

Current Members

Postdoctoral Fellows

Tom Everett
Tom Everett
PhD, Postdoctoral Fellow
Project: Molecular Motors
(573) 884-3356 | everettt@missouri.edu

B.S., 2004, Chemistry, Truman State University
Ph.D., 2010, Analytical/Materials Chemistry, Kansas State University
Postdoctoral Fellow, July 2010-Present, International Institute of Nano and Molecular Medicine, University of Missouri-Columbia

My research interests are focused on nano-materials, the integration of nano materials into everyday life, and in optical and scanning probe microscopies and their use for the characterization of nano-materials.  Currently I am studying novel polymeric compounds using atomic force microscopy, we expect that some of these polymeric materials will show semi-conducting behavior and may eventually find use as conductive molecular wires in electronic devices. 

Recipient of Phi Lambda Upsilon’s Outstanding Researcher Award, 2009, Kansas State University

  1. Trajectory angle determination in one dimensional single molecule tracking data by orthogonal regression analysis”; Khanh Hoa Tran Ba, Thomas A. Everett, Takashi Ito, Daniel A. Higgins;, Phys. Chem. Chem. Phys., 2011, 13, 1827-1835.
  2. Electrostatic Self-Assembly of Ordered Perylene-Diimide/Polyelectrolyte Nanofibers in Fluidic Devices: Nematic Domains to Macroscopic Alignment”; Thomas A. Everett, Daniel A. Higgins;, Langmuir; 2009, 25 (22), pp 13045-13051.
  3. Aggregation and its Influence on Macroscopic In-Plane Organization in Thin Films of Electrostatically Self-Assembled Perylene-diimide/Polyelectrolyte Nanofibers”; Corey R. Weitzel, Thomas A. Everett, Daniel A. Higgins;,  Langmuir;2009;25 (2), pp 1188-1195.
  4. “Preparation and Characterization of Nanofibrous Perylene-Diimide—Polyelectrolyte Composite Thin Films”, Thomas A. Everett, Amy A. Twite, Aifang Xie, Srinivas K. Battina, Duy H. Hua, and Daniel A. Higgins; Chemistry of Materials; 2006; 18(25); 5937-5943.
  5. “High-resolution direct-write multiphoton photolithography in poly(methylmethacrylate) films”, Daniel A. Higgins, Thomas A. Everett, Aifang Xie, Sarah M. Forman, and Takashi Ito,Applied Physics Letters, 88, 2006, 184101.
Monika Golebiowska
Monika VanGordon
PhD, Postdoctoral Fellow
Project: (under construction)
vangordonm@missouri.edu

M.S. Chemistry, University of Wroclaw, Poland, 2007
M.S. Physics, University of Missouri, Columbia, MO, USA, 2011
Ph.D. Physics, Universite Montpellier 2, Montpellier, France, 2011

Research area:
Computational molecular modeling studies on borane and carborane containing molecules

Research interests:
Computational chemistry: connection between molecular and electronic structure and function, protein folding, hydrogen bonding, phenomena occurring at interfaces: adsorption, phase transitions, diffusion and biomineralization.

[1] M. Golebiowska, L. Firlej, B. Kuchta, R. Fabianski “Structural transformations of nitrogen adsorbed on graphite: Monte Carlo studies of spatial heterogeneity in multilayer system”, J. Chem. Phys. 2009, 130(20):204703
[2] M. Golebiowska, M. Roth, L. Firlej, B. Kuchta, C. Wexler “The reversibility of the adsorption of methane-methyl mercaptan mixtures in nanoporous carbon”, Carbon 2012, 50, 225-234

Aslam Khan
Aslam Khan
PhD, Postdoctoral Fellow
Project: Boron Neutron Capture Therapy (BNCT)
(573) 882-0382 | khanasl@missouri.edu

M. S., Dr B.R. Ambedkar University, Agra, India 2000

Ph.D., University of Pune, Pune, India 2006

Postdoctoral Fellow,

  1. Washington University in St Louis 2006-2010
  2. University of Missouri, Columbia 2010- Present

My research interests are focused on developing tumors in mice by implanting different murine cell lines subcutaneously; study distribution of boron-rich compounds in tumors along with organs like liver, blood etc. for their application in BNCT; testing anti-cancer compounds developed at Institute on various cancer cell lines.

Alston Callahan Postdoctoral Scholar Award, International Retina Research Foundation (2009-present)
Senior Research Fellow Award, Council of Scientific and Industrial Research, India (2003-2006)
Junior Research Fellow Award, Council of Scientific and Industrial Research, India (2001-2003)
University Grant Commission Distinguished Lectureship Award, India (Dec 2000)
Indian Council of Medical Research Distinguished Project Fellowship Award, India (2001)
Best Poster Award, Indian Immunological Society, India (2004)

  1. Khan AA, Dace D, Ryazanov AG, Kelly J, & Apte R. Resveratrol regulates Pathologic Angiogenesis by a Sirt1 independent and eukaryotic elongation factor-2 kinase dependent pathway. American Journal of Pathology (In press).
  2. Kelly J, Khan AA, Yin J, Ferguson TA, Apte RS. Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. Journal of Clinical Investigation. 2007; 117(11):3421-6
  3. Awasthi A, Mathur R, Khan AA, Joshi BN, Jain N, Sawant S,  Boppana  R,  Mitra D, Saha B. CD40 signaling is impaired in L. major-infected  macrophages  and is rescued by a p38MAPK activator establishing a  host-protective  memory  T cell response. Journal of Experimental Medicine. 2003; 197 (8): 1037-43
  4. Khan AA, Martin S, Saha B. SEB induced signaling in macrophages leads to biphasic TNF-a. Journal of Leukocyte Biology.  2008; 83(6):1363-9
  5. Khan AA, Apte R. An assay for macrophage mediated regulation of endothelial cell proliferation. Immunobiology. 2008; 213(9-10):695-9.
  6. Khan AA, Priya S, Saha B. IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice. Public Library of Science One (electronic version). 2009; 4(12):e8473: 1-6
  7. Dace DS, Khan AA, Stark JL, Kelly J, Cross AH, Apte RS. Interleukin-10 over expression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy. Public Library of Science One (electronic version). 2009; 4(9):e7121:1-11
  8. Dace DS, Khan AA, Kelly J, & Apte R. Interleukin-10 Promotes Pathological Angiogenesis by Regulating Macrophage Response to Hypoxia during Development. Public Library of Science One (electronic version). 2008; 3(10):e3381:1-10 
Presentations
  1. Khan AA, Dru S, Kelly J, and Apte RS.  Resveratrol regulates Pathologic Angiogenesis by eukaryotic elongation factor-2 kinase dependent pathway. (Association for Research in Vision and Ophthalmology) May 2-6 2010.
  2. Khan AA, Kelly J, and Apte RS.  Resveratrol Inhibits Post-developmental Angiogenesis by eEF-2 Kinase Mediated Phosphorylation of Elogantion Factor-2 (eEF-2). Postdoctoral Symposium at Washington University in St. Louis, Missouri-63110, Feb 2008.
  3. Khan AA and Saha B. MHC-II-G Protein: A novel interaction leading to TNF-a production in APCs. Indian Immunology Society, 31st Annual Conference. Anna University, Chennai, India.  Dec.  15-18, 2004
Peter Kueffer
Peter J. Kueffer
PhD, Research Chemist
Project: Liposomes/OPD, Magnetic Resonance Imaging (MRI)
(573) 884-3356 | kuefferp@missouri.edu

B.S., 2002, Chemistry; Ph.D., 2008, Inorganic Chemistry and Analytical Chemistry: University of Arizona

Experience

Contract Chemist: Cognis Corporation - August 2002 to August 2003

Teaching Assistant: University of Arizona – August 2003 to May 2008

Postdoctoral Fellow: International Institute of Nano and Molecular Medicine – August 2008-present

Chronologically, my primary interests have evolved from the original focus on the rational design of supramolecular constructs, mediated by the [Re6Se8]2+ cluster core, through the usage of hydrogen bonding and coordination interactions. This developed into a more generalized interest in the orbital structure and bonding capabilities of the [Re6Se8]2+ cluster core (and of clusters in general), leading to an emphasis on the elucidation of its fundamental chemical capabilities with priority given to organometallic chemistry, small ligand transformation, and catalysis. More recently, concentration has shifted to the investigation of boron cluster and carborane derivates for implementation as novel MRI constrast reagents and cancer therapeutics with concomitant exploration of delivery pathways.

Mid-Career Fellowship (2004 and 2005) - These yearly fellowships are awarded to outstanding graduate students in the Chemistry Department at the University of Arizona.

ACRE Fellowship (2001) - Grant awarded by Merck for undergraduate research with emphasis on chemical synthesis.

Regent’s Waiver (1997) - Tuition waiver to an Arizona college given to the top 10% of the graduating high school class.

Please note name change from Orto to Kueffer.

Novel Concentration-Driven Structural Interconversion in Shape-Specific Solid Supported by the Octahedral [Re6(μ3-Se)8]2+ Cluster Core.” Selby, H. D.; Orto, P.; Carducci, M. D.; Zheng, Z. Inorg. Chem. 200241, 6175.

Supramolecular Arrays of the [Re6(μ3-Se)8]2+ Core-Containing Clusters Mediated by Transition Metal Ions.” Selby, H. D.; Orto, P.; Zheng, Z. Polyhedron200322, 2999.

Alcohol Addition to Acetonitrile Activated by the [Re6(μ3-Se)8]2+ Cluster Core.” 
Orto, P.; Selby, H. D.; Ferris, D.; Maeyer, J. R.; Zheng, Z.Inorg. Chem200746, 4377.

Cluster Carbonyls of the [Re6(μ3-Se)8]2+ Core.”Orto, P. J.; Nichol, G. S.; Wang, R.; Zheng, Z.Inorg. Chem200746, 8436.

Cluster Carbonyls of the [Re6(μ3-Se)8]2+ Core: Synthesis, Structural Characterization, and Computational Analysis.Orto, P. J.; Nichol, G. S.; Okumura, N.; Evans, D. H.; Arratia-Pérez, D. H.; Ramirez-Tagle, R.; Wang, R.; Zheng, Z. Dalton Trans. 2008, 4247.

Presentations

Aspects of the Inorganic, Organometallic, and Catalytic Potential of [Re6(μ3-Se)8]2+ Core-Containing Cluster Derivatives: Synthesis, Characterization, Computational Analysis and Applications” Kueffer, P. Final seminar to the Department of Chemistry, University of Arizona, Tucson, AZ, April 1, 2008.

Alcohol Addition to Acetonitrile Activated by the [Re6(μ3-Se)8]2+ Cluster Core: Unexpected Predominant Formation of the Stereochemically Less Favored Imino Ester Complex.” Orto, P.; Selby, H. D.; Ferris, D.; Zheng, Z. Department of Chemistry,  University of Arizona, Tucson, AZ. Presentation at 19th Rocky Mountain Regional Meeting of the American Chemical Society, Tucson, AZ, United States, October 14-18, 2006.

Alexei Pushechnikov
Alexei Pushechnikov
PhD, Postdoctoral Fellow
Project: Dendritic Closomers, Nanomedicine and Drug Delivery
(573) 884-4659 | pushechnikovo@missouri.edu

B.S. Chemical Engineering, Institute of Chemical Technology, Dnepropetrovsk, Ukraine, 1994
M.S. Chemical Engineering, National Technical University "Kiev Polytechnic Institute", Kiev, Ukraine, 1996
Ph.D. Element-Organic Chemistry, Research Institute of Organic Chemistry of National Academy of Sciences, Kiev, Ukraine, 2000.

Postdoctoral Fellow, State University of New York at Buffalo, 2007 - 2009.

Postdoctoral Fellow, University of Wisconsin - Madison, 2003 - 2006
Research Associate, Natural Resources Research Institute, University of Minnesota, 2001 - 2003.

Heterocyclic Compounds - Design and synthesis of heterocyclic molecules for light-emitting, light-harvesting, electro-optic and photonic materials. Development of novel molecular probes (dyes and photoluminescent compounds) for sensors, screening assays and bio-imaging applications. Synthesis of phosphorus-containing heterocyclic systems and their application as ligands for transition metal complexes as well as for fabrication of organic/inorganic hybrids.

Natural Products and Medicinal Chemistry - Synthetic modification of aminoglycoside antibiotics. Development of new diversity-oriented synthetic methodologies for obtaining small molecule libraries. Conjugation of bioactive compounds with fluorescent probes for the detailed studies of binding modes with relevant biological targets.

Award of Ministry of Education of Ukraine, 1993
Fellowship of National Academy of Sciences of Ukraine for Outstanding Graduate Research, 1998 - 2000

  1. A Chemoenzymatic Route to Diversify Aminolgycosides Enables A Microarray-Based Method to Probe Acetyltransferase Activity. Tsitovich, P. B.; Pushechnikov, A.; French, J. M.; Disney, M. D. ChemBioChem 2010, 11, 1656-1660.
  2. Controlling the Specificity of Modularly Assembled Small Molecules for RNA via Ligand Module Spacing: Targeting the RNAs That Cause Myotonic Muscular Dystrophy. Lee, M. M.; Childs-Disney, J. L.; Pushechnikov, A.; Sobczak, K.; French, J. M.; Thornton, C. A.; Disney, M. D. J. Am. Chem. Soc. 2009, 131, 17464-17472.
  3. Rational Design of Ligands Targeting Triplet Repeating Transcripts That Cause RNA Dominant Disease: Application to Myotonic Muscular Dystrophy Type 1 and Spinocerebellar Ataxia Type 3. Pushechnikov, A.; Lee, M.; Childs-Disney, J. L.; Sobczak, K.; French, J. M.; Thornton, C. A.; Disney, M. D. J. Am. Chem. Soc. 2009, 131, 9767-9779.
  4. Rational and Modular Design of Potent Ligands Targeting the RNA that Causes Myotonic Dystrophy 2. Lee, M.; Pushechnikov, A.; Disney, M. D. ACS Chem. Biol. 2009, 4, 345-355.
  5. Small Molecule Microarrays of RNA-Focused Peptoids Help Identify Inhibitors of a Pathogenic Group I Intron. Labuda, L. P.; Pushechnikov, A.; Disney, M. D. ACS Chem. Biol. 2009, 4, 299-307.
  6. The Stereochemistry of Allenic Enol Tautomerism; Independent Generation and Reactivity. Zimmerman, H. E.; Pushechnikov, A. Eur. J. Org. Chem. 2006, 3491-3497.
  7. Electron-Rich Aminoheterocycles for Regiospecific Synthesis of CF3-containing Fused Pyridines. Volochnyuk, D. M.; Pushechnikov, A.; Krotko, D. G.; Sibgatulin, D. A.; Kovalyova, S. A.; Tolmachev, A. A. Synthesis 2003, 1531-1540.
  8. Novel heterocyclic system - 2,4,1-benzoxazaphosphinine: convenient substrate for synthesis of derivatives of 2,4-diaminophenylphosphonic acid. Pushechnikov, A.; Krotko, D. G.; Volochnyuk, D. M.; Tolmachev, A. A. Synlett 2001, 6, 860-862.
Suarav Sarma
Suarav J. Sarma
PhD, Postdoctoral Fellow
Project: Closomer Chemistry
(573) 882-0382 | sarmas@missouri.edu

Ph.D. in Organic Chemistry, 2011
Department of Chemistry, Wake Forest University
Winston Salem, NC 27109, USA
 
M.S. in Organic chemistry, 2005

Department of Chemistry, University of Delhi, Delhi, India 110007

Experience

Aug, 2005- July 2006  Teaching Assistant, Department of Chemistry, Wake Forest University, NC, USA

Aug, 2006- Dec, 2007 Research Assistant, Department of Chemistry, Wake Forest University, NC, USA

Jan, 2008- Dec, 2010 Spectroscopy Teaching Assistant, in the Department of Chemistry, Wake Forest University.

Past experience include H-abstraction, single electron transfer (SET), C-H bond homolysis and
oxidative radical cyclization reactions of alkoxy- anthraquinones and their analogues. Design of potential alternative candidate for photodynamic therapy in absence of oxygen. Photochemical conversion of alcohols to alkane and alkyl halides.

Present research focuses on synthesis of high payload drug delivery agents as well as MRI contrast agents based on nanoscale polyhedral-boranes. 

Sarma, Saurav J.; Jones, Paul B. Photo Induced Electron Transfer and Oxidative Radical Cyclization Reactions of 1-Substituted-9,10-Anthraquinones. 59th Southeast Regional Meeting of the American Chemical Society, Greenville, SC, United States, October 24-27 (2007).

Sarma, Saurav J.; Jones, P. B. Photoinduced Electron Transfer in 1-substituted -9,10-anthraquinones. 40th National Organic Symposium of the American Chemical Society, Duke University, Durham, NC, United States, Jun 3-7 (2007).

Sarma, S. J.; Jones, P. B. Photochemistry of 1,n-Dibenzyloxy-9,10-anthraquinones. Journal of Organic Chemistry (2010), 75(11), 3806-3813.

Jones, P. B.; Brinson, R. G.; Sarma, S. J.; Elkazaz, S. Observation of heavy atom effects in the development of water soluble caged 4-hydroxy-trans-2-nonenal. Organic & Biomolecular Chemistry (2008), 6(22), 4204-4211.

Natasha Shlyakhtina
Natasha Shlyakhtina
PhD, Research Chemist
Project: Molecular Motors
(573) 884-3356 | shlyakhtinan@missouri.edu

B.S./M.S., 1999, Irkutsk State Technical University (Irkutsk, Russia)

Ph.D., 2002, A.E. Favorskii Irkutsk Institute of Chemistry, Siberian Branch ofthe Russian Academy of Sciences (Irkutsk, Russia). Title: “Reactions of metallated heteroalkenes, alkynes and 1,2-diens with heterocumulenes: a new approach to the synthesis of functional N-, O-, S-heterocycles”.

Our group specializes in the synthetic chemistry of carboranes and their metallic derivatives. The research project involves the development of new nano-sized molecular motors with biomedical and material sciences applications.

  1. Nedolya N.A., Schlyakhtina N.I., Zinov,eva V.P., Albanov A.I., Brandsma L. Synthesis and Ag+-catalyzed Cyclization of 2,3-Dienamides. Tetrahedron Lett. 2002. Vol. 43. # 8. P. 1569-1571.
  2. Nedolya N.A., Schlyakhtina N.I., Klyba L.V., Ushakov I.A., Fedorov S.V., Brandsma L. Synthesis and easy aromatisation of 5-substituted 6-(alkylthio)-2-methohy-2,3-dyhydropyridines. A new approach to the pyridine ring. Tetrahedron Lett. 2002. Vol. 43. P. 9679-9681.

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Graduate Students

Shatadru Chakravarty
Graduate Student
Project: Magnetic Resonance Imaging (MRI) Contrast Agents
(573) 884-3356 | scym8@missouri.edu

B.Sc. Banaras Hindu University, U.P. India, May 2005
M.Sc. Banaras Hindu University, U.P. India, May 2007

The role of metal ions within the human body is equally immense and fascinating. Chelating these metals ions with optimal ligands can lead to control over their properties and mode of action. My research goal involves the synthesis and characterization of such ligands and their complexation with metal ions to form systems that can be used for varied applications in medicine. A deeper understanding of the possible interactions between such complexes with biological systems can lead to design of novel platforms for imaging and drug delivery. My graduate research work focuses on the synthesis of closo-borane based MRI contrast agents. This involves multi-gram synthesis of novel poly-amino carboxylate ligands. Further conjugation with various modified closo- borane platforms, followed by complexation with Gd3+ ion would lead to contrast agents with enhanced relaxivity values.

Ramanujam Schlarship (All India Mathematics Olympiad)
Qualified National Eligibility Test (NET) and Graduate Aptitude Test in Engineering (GATE)

Extensions of the Icosahedral Closomer Structure by Using Azide–Alkyne Click Reactions, Angewandte Chemie, International Edition (2011), 50(20), 4689-4691
Zachary H. Houston
Graduate Student
Project: Drug Delivery
(573) 884-4659 | zhh1f5@missouri.edu

B.S., 2006, Biomedical Nanotechnology (1st Class Honours), Flinders University, South Australia, Australia.

M.S., 2010, Chemistry, University of Missouri, USA.

Ph.D., 2008-Present, University of Missouri, USA.

My interests lie in developing “smart drugs” or drug delivery systems which are able to selectively target, penetrate, and efficaciously deliver a therapeutic payload.  This type of drug delivery is responsive to its environment and is highly tunable.  Chemically, these delivery systems are multifaceted and involve the use of multiple motifs and a central scaffold for attachment.  I am currently utilizing a closo-borane core as a drug delivery platform and developing suitable organic linkers for the attachment of therapeutic, diagnostic, targeting, and other such functionalities to the nanomolecular drug delivery platform.

S.P.I.E. Educational Scholarship in Optical Science and Engineering

NASA - Missouri Space Grant Consortium Honors Research Scholarship

Honours Research Project at Flinders University (H1 Scholarship)

Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery. Lalit N. Goswami, Zachary H. Houston, Saurav J. Sarma, Satish S. Jalisatgi and M. Frederick Hawthorne. Org. Biomol. Chem., 2013, 11, pp 1116-1126.

Synthesis of Vertex-Differentiated Icosahedral closo-Boranes: Polyfunctional Scaffolds for Targeted Drug Delivery. Lalit N. Goswami, Zachary H. Houston, Saurav J. Sarma, Hairong Li, Satish S. Jalisatgi and M. Frederick Hawthorne. J. Org. Chem., 2012, 77 (24), pp 11333–11338.

A Convenient Route to Diversely Substituted Icosahedral Closomer Nanoscaffolds. Satish S. Jalisatgi, Vikas S. Kulkarni, Betty Tang, Zachary H. Houston, Mark W. Lee, Jr., and M. Frederick Hawthorne.  J. Am. Chem. Soc., 2011, 133 (32), pp 12382–12385.

Use of Hydrogen Plasma for Storing Hydrogen in Nanophase Diamond PowderZach Houston, Tushar K. Ghosh, and Mark A. Prelas. ANS Transactions, American Nuclear Society, 2005, 92, pp 88-99.

Charlie Maitz
Charlie A. Maitz
DVM, Veterinary Resident and PhD Candidate
Project: Boron Neutron Capture Therapy (BNCT)
(573) 882-0382 | maitzc@missouri.edu

BS, Biology, University of Missouri, 2004
Doctor of Veterinary Medicine (DVM), University of Missouri, 2009
Veterinary Internship (Small Animal Medicine and Surgery), Bay Area Veterinary Specialists, 2009-2010
Veterinary Residency (Radiation Oncology), 2010-present
PhD student (Radiochemistry), 2010-present

My research interests lie in the interactions of radiation with biologic systems, specifically in the development of novel approaches to improving radiation therapy of cancer.  Central to this interest is the study of Boron Neutron Capture Therapy and its application to clinical situations in naturally occurring tumors.  I am also interested in the development and understanding of agents that can be given to prevent or lessen the effects of radiation on biologic systems.

ACVR Senior Student Award, 2009 – This award is given by the American College of Veterinary Radiologists to a single clinical student in each veterinary college who excels in veterinary radiology.

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Undergraduate Students

Melissa Luechtefeld
Melissa Luechtefeld
Undergraduate Lab Assistant
Project: Boron Neutron Capture Therapy (BNCT)
mel387@missouri.edu
Chimwemwe Manda
Chimwemwe Manda
Undergraduate Lab Assistant
Project: Molecular Motors
cmt32@missouri.edu
Dalton Smedley
Dalton Smedley
Undergraduate Lab Assistant
Project: Mass Spectrometry
gdsm2b@missouri.edu
Doanh Tran
Doanh Tran
Undergraduate Lab Assistant
Project: Molecular Motors
dxtnp7@mail.missouri.edu
Andrew Muelleman
Undergraduate Lab Assistant
Project: Magnetic Resonance Imaging (MRI)
awmnbb@missouri.edu

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Alumni

Oleg Bondarev
Oleg Bondarev
PhD, Postdoctoral Fellow
Project: Catalytic Activation of Carboranes, Nano-medicine and Drug Delivery

 

Catherine Bridges
Catherine Bridges
Undergraduate Lab Assistant
Project: (under construction)
clbn96@missouri.edu

 

Shuyi Cai
Shuyi Cai
PhD, Postdoctoral Fellow
2007-2009
Project: Liposomes/OPD
Karen Chan
Karen K. Chan
Graduate Student (UCLA), PhD
2009
Project: Targeted Drug Delivery
Amanda Dennis
Amanda C. Dennis
Graduate Student (UCLA), PhD
2009
Project: Magnetic Resonance Imaging (MRI) Contrast Agents
Christine Eidson
Christine Eidson
Undergraduate Researcher
2009-2011
Project: Boron Neutron Capture Therapy (BNCT)
Arsen Galustyan
Arsen Galustyan
Graduate Student
2007-2010
Project: Oligomeric Phosphate Diesters, Liposomes
Sarah Higdon
Sarah Higdon
Undergraduate Lab Assistant
2009-2012
Project: Boron Neutron Capture Therapy (BNCT)
Richard Julius
Richard J. Julius
Graduate Student (UCLA), PhD
2009
Project: Liposomes/OPD
Hanbaek Lee
Hanbaek Lee
PhD, Postdoctoral Fellow
2008-2010
Project: Hydrogen Storage
Calvin Lewis
Calvin D. Lewis
Undergraduate Researcher
Project: Liposomes/OPD
Hairong Li
Hairong Li
PhD, Postdoctoral Fellow
2009-2011
Project: Drug Delivery
Radha Kishan Motkuri
Radha Kishan Motkuri
PhD, Postdoctoral Fellow
2008-2010
Project: Molecular Motors
Vikas Kulkarni
Vikas Kulkarni
PhD, Postdoctoral Fellow
2008-2010
Project: Drug Delivery
Alok Paital
Alok Ranjan Paital
PhD, Postdoctoral Fellow
2009-2011
Project: Molecular Motors
Lucas Rice
Lucas Rice
Undergraduate Lab Assistant
Project: Drug Delivery
lijrk99@missouri.edu

 

Ram Pichaandi
Ram Pichaandi
PhD, Postdoctoral Fellow
2008-2010
Project: Carborods
Oscar Tutusaus Santandreu
Oscar Tutusaus Santandreu
PhD, Postdoctoral Fellow
2009-2010
Project: Closomer / Vertex Differentiation
Seth Schuster
Laboratory Technician 
2009-2013
Project: BNCT
Betty Tang
Betty Tang
Graduate Student (UCLA), PhD
2008
Project: Drug Delivery
Andrew Tsao
Student Assistant, Web Development
2009-2012
Xiaoyan Tu
Xiaoyan Tu
PhD, Postdoctoral Fellow
2010-2011
Project: Drug Delivery
Cecilia Urrutia
Cecilia Urrutia
Undergraduate Lab Assistant
Project: Magnetic Resonance Imaging (MRI)
cau6w3@missouri.edu

 

Craig Woody
Student Assistant, Lab Orders
2008-2011
Jianguo Wu
Jianguo Wu
PhD, Postdoctoral Fellow
2008-2009
Project: Hydrogen Storage
Shuo Yang
Shuo Yang
Graduate Student, PhD
2010
Project: Magnetic Resonance Imaging (MRI) Contrast Agents
Zhi Yang
Zhi Yang
PhD, Postdoctoral Fellow
2007-2008
Project: Molecular Motors

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