Research Assistant Professor

Alexander Safronov received his undergraduate degree from Moscow State University of Fine Chemical Technology in 1998 and his PhD from Nesmeyanov Institute of Organoelement Compounds (INEOS RAS) in 2005. After completing his PhD he gained industrial experience in drug discovery and combinatorial chemistry at Chembridge Corporation, Moscow. In 2006, he joined I²NM² as a postdoctoral researcher and in 2008 he was appointed a Research Assistant Professor at the Institute. His research is in chemistry, biological, and material applications of polyhedral boron clusters. He is particularly interested in the development of new synthetic ways to substituted boranes, carboranes and metallacarboranes.

 

Alexander Safronov

Alexander V. Safronov

(573) 882-7031

safronova@missouri.edu

Research Area

  • Carborane-based low-dimensional nanomaterials
  • Molecular motors
  • Chemical hydrogen storage

Research Interests:

The research interest of the institute is focused on synthesis and characterization of carborane-based low dimensional-materials, such as rods and wires. A lot of work is concentrated on developing the conception of carborane-based molecular motors and their application in nano-materials. We are also carrying out research on application of polyhedral borane anions as hydrogen source for hydrogen-powered vehicles.

Education

B.S., 1998; M.S., 2000, M. V. Lomonosov State Academy of Fine Chemical Technology (Moscow, Russia)
Ph.D., 2005, A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (Moscow, Russia)

Awards

Bayer Scholarship 2002

Selected Publications

Peer-reviewed Journal Publications

A. V. Safronov, S. S. Jalisatgi, M. F. Hawthorne. Novel Convenient Synthesis of 10B-Enriched Sodium Borohydride. Inorg. Chem., 2016, 55, 5116-5117

A. V. Safronov, D. X. Tran, Y. S. Sevryugina, S. S. Jalisatgi, M. F. Hawthorne. Facile Synthesis of Mixed-Ligand Bis(dicarbollyl) Complexes of Nickel, J. Organomet. Chem., 2016, 805, 15-18

N. I. Shlyakhtina, A. V. Safronov, Y. S. Sevryugina, S. S. Jalisatgi, M. F. Hawthorne. Synthesis, characterization, and preliminary fluorescence study of a mixed-ligand bis(dicarbollyl)nickel complex bearing a tryptophan-BODIPY FRET couple. J. Organomet. Chem., 2015, 798, 234-244

K. Z. Kabytaev, A. V. Safronov, Y. V. Sevryugina, C. L. Barnes, S. S. Jalisatgi, M. F. Hawthorne. Novel synthetic approach to charge-compensated phosphonio-nido-carboranes. Synthesis and structural characterization of neutral mono and bis(phosphonio) nido-ortho-carboranes. Inorg. Chem. 2015, 54, 4143-4150

A. V. Safronov. Boron neutron capture therapy of cancer as a part of modern nanomedicine. Int. J. Med. Nano Res. 2014, 1:1

A. V. Safronov, N. I. Shlyakhtina, T. A. Everett, M. R. VanGordon, Y. V. Sevryugina, S. S. Jalisatgi, M. Frederick Hawthorne. Direct observation of bis(dicarbollyl)nickel conformers in solution by fluorescence spectroscopy: an approach to redox-controlled metallacarborane molecular motors. Inorg. Chem. 2014, 53, 10045-10053

A. V. Safronov, K. Z. Kabytaev, S. S. Jalisatgi, M. F. Hawthorne. Novel iodinated carboranes: synthesis of the 8-iodo-7,9-dicarba-nido-undecaborate anion and 2-iodo-1,7-dicarba-closo-dodecaborane. Dalton Trans. 2014, 43, 12467-12469

A. V. Safronov, Y. V. Sevryugina, K. R. L. Pichaandi, S. S. Jalisatgi, M. F. Hawthorne. Synthesis of closo- and nido-biscarboranes with rigid unsaturated linkers as precursors to linear metallacarborane-based molecular rods. Dalton Trans. 2014, 43, 4969-4977

K. Z. Kabytaev, A. V. Safronov, S. S. Jalisatgi, M. F. Hawthorne. Synthesis and reactions of B-vinylcarboranes. J. Organomet. Chem. 2014, 749, 106-108

K. Z. Kabytaev, T. A. Everett, A. V. Safronov, Y. V. Sevryugina, S. S. Jalisatgi, M. F. Hawthorne. B-Mercaptocarboranes: a new synthetic route. Eur. J. Inorg. Chem. 2013, 2488-2491

A. V. Safronov, N. I. Shlyakhtina, M. F. Hawthorne. A new approach to the synthesis of 3-alkyl-1,2-dicarba-closo-dodecaboranes: reaction of alkyldichloroboranes with thallium dicarbollide. Organometallics 2012, 31, 2764-2769

A. V. Safronov, Y. V. Sevryugina, S. S. Jalisatgi, R. D. Kennedy, C. L. Barnes, M. F. Hawthorne. An unfairly forgotten member of the iodocarborane family: synthesis and structural characterization of 8-iodo-1,2-dicarba-closo-dodecaborane, its precursors and derivatives. Inorg. Chem. 2012, 51, 2629-2637

A. V. Safronov, S. S. Jalisatgi, H. B. Lee, M. F. Hawthorne. Chemical hydrogen storage using polynuclear borane anion salts. Int. J. Hydrogen Energy 2011, 36, 234-239

A. V. Safronov, M. F. Hawthorne, Novel synthesis of 3-iodo-ortho-carborane. Inorg. Chim. Acta 2011, 375, 308-310

M. F. Hawthorne, S. S. Jalisatgi, A. V. Safronov, H. B. Lee, J. Wu. Chemical hydrogen storage using polyhedral borane anions and aluminum-ammonia-borane complexes. Technical report, DOE Center of Excellence for chemical hydrogen storage, DOE/GO/15058, DE-FC36-05GO15058, 2010 (DOI: 10.2172/990217)

L. S. Alekseev, A. V. Safronov, F. M. Dolgushin, A. A. Korlyukov, I. A. Godovikov, I. T. Chizhevsky. An unexpected cluster opening upon the formation of electronically unsaturated η3-(cyclooctenyl)metallacarboranes of rhodium(III) and iridium(III) with sterically reduced [(PhCH2)2C2B9H9]2− ligand. J. Organomet. Chem. 2009, 694, 1727-1735

A. V. Safronov, F. M. Dolgushin, P.V. Petrovskii, I. T. Chizhevsky. Low-temperature "1,2→1,7" isomerization of sterically crowded icosahedral closo-((2,3,8-η3):(5,6-η2)-norbornadien-2-yl)rhodacarborane via the formation of a pseudocloso intermediate. Molecular structures of [3,3-((2,3,8-η3):(5,6-η2)-C7H7CH2)-1,2-(4-MeC6H4)2-3,1,2- pseudocloso-RhC2B9H9] and 1,2 → 1,7 isomerized products. Organometallics 2005, 24, 2964-2970

A. V. Safronov, M. N. Sokolova, E. V. Vorontsov, P. V. Petrovskii, I. G. Barakovskaya, I. T. Chizhevsky. Formation of closo-rhodacarboranes with η23-(CH2=CHC5H6) ligand in the reaction of [(η4-COD)RhCl]2 with carborane salts [K][nido-7-R1-8-R2-7,8- C2B9H10]. Russ. Chem. Bull. (Int. Ed.) 2004, 53, 1954-1957

A. V. Safronov, T. V. Zinevich, F. M. Dolgushin, O. L. Tok, E. V. Vorontsov, I. T. Chizhevsky. Stable agostic (C-H...M) closo-irida- and closo-rhodacarboranes with σ,η2_Cyclooctenyl ligands. Crystal and molecular structure of closo-3,3-(σ,η2-C8H13)- 1,2-μ-(ortho-xylylene)-3,1,2-IrC2B9H9. Organometallics 2004, 23, 4970-4979

A. V. Safronov, T. V. Zinevich, F. M. Dolgushin, E. V. Vorontsov, O. L. Tok, I. T. Chizhevsky. First agostic closo-metallacarboranes with η3-cyclooctenyl type ligand: synthesis and structural characterization of closo-3-[η3_(endo-1,5-dimethylcycloocten-¬1-yl)]-1,2-µ-(1’,2’-xylylene)-3,1,2-IrC2B9H9 and its isomerization to closo-3-[η3-(exo-1- methylene-5-methylcyclooctene-1-yl)]-1,2-µ-[η2-(1’,2’-xyIyIene)]-3,1,2-IrC2B9H9. J. Organomet. Chem. 2003, 680, 111-123

T. V. Zinevich, A. V. Safronov, E. V. Vorontsov, P. V. Petrovskii, I. T. Chizhevsky. Simple and efficient synthesis of closo-rhoda- and closo-iridacarboranes with π-ligands based on cyclic dienes. Russ. Chem. Bull. (Int. Ed.) 2001, 50, 1702-1704

T. V. Zinevich, A. V. Safronov, F. M. Dolgushin, O. L. Tok, I. T. Chizhevsky. closo-3-(η3-4,6-Dimethylbicyclo[3.3.0]oct-1-en-2-yl)-1,2-dimethyl-3,1,2-dicarbollyl-iridium with an agostic C-H...Ir bond. Russ. Chem. Bull. (Int. Ed.) 2001, 50, 2254-2255

Book Chapters

M. W. Lee, Jr., A. V. Safronov, S. S. Jalisatgi, M. F. Hawthorne. Cesium dodecahydroxy-closo-dodecaborate, Cs2[B12(OH)12], Inorganic Syntheses, v. 35, p. 63-66 (2010).

Patents/Patent Applications

A. V. Safronov, S. S. Jalisatgi, M. F. Hawthorne. Synthesis of borane compounds, WO 2015/117119 A1, 2015

A. V. Safronov, S. S. Jalisatgi, M. F. Hawthorne. Synthesis of amine boranes and polyhedral boranes, WO 2015/117123 A1, 2015

Conference Theses

A. V. Safronov, S. S. Jalisatgi, M. F. Hawthorne. Production of 10B-enriched materials at the International Institute of Nano and Molecular Medicine, University of Missouri-Columbia (plenary presentation). 17th International Conference on Neutron Capture Therapy, Columbia, Missouri, USA, 2016

A.R. Karikacheri, A. V. Safronov, T. A. Everett, C. A. Maitz, J.D> Brockman, D. W. Nigg, S. J. Sarma, B. A. Meers, G. M. Ralph, S. N. McMaster, P. J. Kueffer, L. N. Goswami, A. A. Khan, N. I. Shlyakhtina, A. Durairaj, S. S. Jalisatgi, M. F. Hawthorne. The boron neutron capture therapy (BNCT) program at the University of Missouri, International Institute of Nano and Molecular Medicine. 17th International Conference on Neutron Capture Therapy, Columbia, Missouri, USA, 2016

M. F. Hawthorne, S. S. Jalisatgi, P. J. Kueffer, C. A. Maitz, A. A. Khan, O. Pushechnikov, T. A. Everett, A. V. Safronov, D. W. Nigg, J. D. Brockman. Boron-rich liposomes as nanoscale delivery agents for BNCT, 16th International Congress on Neutron Capture Therapy, Helsinki, Finland, 2014

N. I. Shlyakhtina, A. V. Safronov, M. F. Hawthorne. New design in the synthesis of nickel bid(dicarbollide) species for the use of FRET. IMEBORON XIV, Niagara Falls, Ontario, Canada, 2011

Y. V. Sevryugina, A. V. Safronov, M. F. Hawthorne, C.F. Campana. B-Iodinated o-carboranes: C-H---I hydrogen bonding, absolute structure determination and merohedral twinning in space group P41. ACA Annual Meeting, New Orleans, LA, United States, 2011 (paper 05.01.5)

I. T. Chizhevsky, F. M. Dolgushin, L. S. Alekseev, A. V. Safronov. closo-Metallacarboranes with hydrocarbon C8-ring ligands: chemistry and structural studies. IMEBORON XIII, Palau de congressos de Platja dÁro, Spain, 2008

M. F. Hawthorne, S. S. Jalisatgi, A. V. Safronov. Chemical hydrogen storage using polyhedral borane anion salts. DOE Hydrogen Project, Annual Merit Review and Peer Evaluation, Washington D.C., USA, 2007

F. M. Dolgushin, I. V. Komkov, A. V. Safronov, I. T. Chizhevsky, M. Yu. Antipin. Structural characterization of new 11- and 12-vertex rhoda- and ruthenacarboranes with polyhedral deformation. EUROBORON-3, Pruhonice, Czech Republic, 2004

A. V. Safronov, M. N. Sokolova, E. V. Vorontsov, P. V. Perovskii, I. T. Chizhevskii. Formation of closo-rhodacarboranes with η2,3-(CH2=CH-C5H6) ligand in the reaction of [(η4-NBD)RhCl]2 with [K][nido-7-R1-8-R2-7,8-C2B9H11] (R1, R2 = Alk, Ar, ArAlk). Modern Trends in Organoelement and Polymer Chemistry, International Conference Dedicated to 50th Anniversary of A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia, 2004

A. V. Safronov, T. V. Zinevitch, F. M. Dolgushin, P. V. Petrovskii, I. T. Chizhevskii. Low temperature "1,2 - 1,7" rearrangement of sterically crowded rhodacarborane closo-3-[η,2,3-C7H7-2-CH2)]-1,2-(4'-C6H4Me)2-3,1,2-RhC2B9H9. Modern Trends in Organometallic and Catalytic Chemistry (Mark Vol'pin Memorial International Symposium), Moscow, Russia, 2003

A. V. Safronov, T. V. Zinevitch, F. M. Dolgushin, P. V. Pertovskii, E. V. Vorontsov, I. T. Chizhevsky. closo-Iridacarboranes with carbocyclic ligands: a new one-pot synthetic procedure. IMEBORON XI, Moscow, Russia, 2002

T. V. Zinevitch, A. V. Safronov, F. M. Dolgushin, P. V. Petrovskii, E. V. Vorontsov, I. T. Chizhevsky. Simple synthetic route to closo-rhoda and closo-iridacarboranes with cyclic hydrocarbon ligands. EUROBORON-2, Dinard, France, 2001

I. V. Pisareva, T V. Zinevitch, F M. Dolgushin, A V. Safronov, V E. Konoplev, I T. Chizhevsky. Mononuclear and polynuclear platinum group metallacarboranes (Ru, Os, Ir). Synthesis and cluster structures. 3rd Russian Conference on Cluster Chemistry "Polynuclear systems and CO2 Activation", Kazan-Tcheboksary, Russia, 2001