ASSISTANT DIRECTOR

Satish S. Jalisatgi received his undergraduate degree and his Ph.D. in Chemistry from the University of Mumbai (formerly known as University of Bombay). After completing his postdoctoral studies at UC Berkeley with Professor Peter C. Vollhardt, at UCLA with Professor Yves Rubin and later with Professor M. Frederick Hawthorne, Jalisatgi joined the University of Missouri in the fall of 2006 as Research Assistant Professor of Radiology. His research interests are in biomedical and material science applications of polyhedral boranes and carboranes. 

 

Satish Jalisatgi

Satish S. Jalisatgi

(573) 884-7099

jalisatgis@missouri.edu

Research Area

Polyhedral Boranes and Carboranes, Drug Delivery, Boron-based Nanomaterials, Boron Neutron Capture Therapy of Cancer (BNCT), Chemical Hydrogen Storage

Research Interests

The majority of the research is focused on developing biomedical and material science applications based upon chemistry of polyhedral boranes and carboranes. These include target specific multifunctional molecular nanomaterials carrying diagnostic and therapeutic functions; use of boranes and carboranes as pharmcophores; and polyhedral boron hydride based chemical hydrogen storage systems.


In addition to synthetic methodologies, we use computational chemistry approaches such as ab initio quantum chemistry methods to study and predict reactivity of carboranes and polyhedral boranes. We also use molecular docking simulations to study interactions of polyhedral borane and carborane containing molecules with proteins and other biomolecules of interest.   

Education

M.Sc. Chemistry, University of Bombay, 1987
Ph.D. Chemistry, University of Bombay, 1993
Postdoctoral Fellow, University of California, Berkeley, 1994-1996
Postdoctoral Fellow, University of California, Los Angeles, 1998-2006

Awards

Merit Scholarship, State of Maharashtra, India. 1984-1986 
Research Fellowship, Department of Science and Technology, India. 1988-1992

Selected Publications

Safronov, A. V.; Tran, D. X.; Sevryugina, Y. V.; Jalisatgi, S. S.; Hawthorne, M. F. “Facile synthesis of mixed-ligand bis(dicarbollyl) complexes of nickel.” J Organomet Chem 2016, 805, 15-18.

Safronov, A. V.; Jalisatgi, S. S.; Hawthorne, M. F. “Novel Convenient Synthesis of B-Enriched Sodium Borohydride.” Inorg Chem 2016.

Kracke, G.; VanGordon, M.; Kabytaev, K.; Sevryugina, Y.; Jalisatgi, S.; Hawthorne, F. “Novel Local Anesthetics Demonstrate Isomer-Dependent Analgesia in Mice.” Biophys J 2016, 110, 446a-447a.

Shlyakhtina, N. I.; Safronov, A. V.; Sevryugina, Y. V.; Jalisatgi, S. S.; Hawthorne, M. F. “Synthesis, characterization, and preliminary fluorescence study of a mixed-ligand bis(dicarbollyl)nickel complex bearing a tryptophan-BODIPY FRET couple.” J Organomet Chem 2015, 798, 234-244.

Kracke, G. R.; VanGordon, M. R.; Sevryugina, Y. V.; Kueffer, P. J.; Kabytaev, K.; Jalisatgi, S. S.; Hawthorne, M. F. Carborane-derived local anesthetics are isomer dependent. Chemmedchem 2015, 10, 62-67.

Kabytaev, K. Z.; Safronov, A. V.; Sevryugina, Y. V.; Barnes, C. L.; Jalisatgi, S. S.; Hawthorne, M. F. “Novel Synthetic Approach to Charge-Compensated Phosphonio-nido-Carboranes. Synthesis and Structural Characterization of Neutral Mono and Bis(Phosphonio) nido-ortho-Carboranes.” Inorg. Chem. 2015, 54, 4143-4150.

Goswami, L. N.; Cai, Q.; Ma, L.; Jalisatgi, S. S.; Hawthorne, M. F. Synthesis, relaxation properties and in vivo assessment of a carborane-GdDOTA-monoamide conjugate as an MRI blood pool contrast agent. Org. Biomol. Chem. 2015, 13, 8912-8918.

Alexander Safronov, Natalia Shlyakhtina, Thomas Everett, Monika VanGordon, Yulia Sevryugina, Satish Jalisatgi, M. Frederick Hawthorne.  “Direct Observation of Bis(dicarbollyl)nickel Conformers in Solution by Fluorescence Spectroscopy: An Approach to Redox-Controlled Metallacarborane Molecular Motors.”  Inorganic Chemistry2014.  Submitted

Alexander V. Safronov, Kuanysh Z. Kabytaev, Satish S. Jalisatgi, M. Frederick Hawthorne.  “Novel Iodinated Carboranes: Synthesis of 8-Iodo-7,9-dicarba-nido-undecaborate Anion and 2-Iodo-1,7-dicarba-closo-dodecaborane.”  Dalton Trans., 2014,   DOI: 10.1039/C4DT00764F.

 Lalit N. Goswami, Aslam A. Khan, Satish S. Jalisatgi and M. Frederick Hawthorne.  “Synthesis and In Vitro Assessment of a Bifunctional Closomer Probe for Fluorine (19F) Magnetic Resonance and Optical Bimodal Cellular Imaging.”  Chem. Commun., 2014, 50 (43), 5793-5795.

Kuanysh Z. Kabytaev, Alexander Valentinovich Safronov, Satish Jalisatgi, M. Frederick Hawthorne.  “Synthesis and Reactions of B-Vinylcarboranes.”  Journal of Organometallic Chemistry. 749 (2014) 106-108.

Alexander Safronov, Yulia Sevryugina, Kothanda Pichaandi, Satish Jalisatgi, M. Frederick Hawthorne. “Synthesis of closo- and nido-Biscarboranes with Rigid Unsaturated Linkers as Precursors to Linear Metallacarborane-Based Molecular Rods.”  Dalton Transactions. 2014, 43 (13), 4969-4977.

Oleg Bondarev, Aslam A. Khan, Xiaoyan Tu, Yulia V. Sevryugina, Satish S. Jalisatgi, M. Frederick Hawthorne.  “The Synthesis of [closo-B12(OH)11NH3]- : A New Heterobifunctional Dodecaborane Scaffold for Drug Delivery Applications.  J. Am. Chem. Society, 2013, 135(35), 13204-13211.

Lalit N. Goswami, Lixin Ma, Peter J. Kueffer, Satish S. Jalisatgi and M. Frederick Hawthorne.  “Synthesis and Relaxivity Studies of a DOTA-based Nanomolecular Chelator Assembly Supported by an Icosahedral Closo-B122- -Core for MRI: A Click Chemistry Approach.”  Molecules 2013, 18(8), 9034-9048.

M. Frederick Hawthorne.  “Interview with M. Frederick Hawthorne.”  Future Medicinal Chemistry. 2013, vol. 5, no. 6, 627-632.

Alexei Pushechnikov, Satish S. Jalisatgi, M. Frederick Hawthorne.  “Dendritic closomers: novel spherical hybrid dendrimers.”  Chem. Commun2013, 49, 3579-3581.

Peter J. Kueffer, Charles A. Maitz, Aslam A. Khan, Seth A. Schuster, Natalia I. Shlyakhtina, Satish S. Jalisatgi, John D. Brockman, David W. Nigg, M. Frederick Hawthorne. “Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes.”  PNAS  vol. 110,
no. 16, 6512-6517 2013.

Kuanysh Kabytaev, Alexander V. Safronov, Thomas A. Everett, Satish S. Jalisatgi, M. Frederick Hawthorne. “B-Mercaptocarboranes: A New Synthetic Route.”  European Journal of Inorganic Chemistry, 2013, 14, 2488-2491.

J. Romanos, M. Beckner, D. Stalla, A. Tekeei, G. Suppes, S. Jalisatgi, M. Lee, F. Hawthorne, J.D. Robertson, L. Firlej, B. Kuchta, C. Wexler, P. Yu, P. Pfeifer.  “Infrared study of boron-carbon chemical bonds in boron-doped activated carbon.”  Carbon2012, 54, 208-214.

Lalit Goswami, Lixin Ma, Quanyu Cai, Saurav Sarma, Satish Jalisatgi, M. Frederick Hawthorne.  “cRGD Peptide-Conjugated Icosahedral closo-B122- Core Carrying Multiple Gd3+ -DOTA Chelates for ανβ3 Integrin-Targeted Tumor Imaging (MRI).”  Inorg. Chem. 2013, 52, 1701-1709.

Lalit Goswami, Zachary Houston, Saurav Sarma, Hairong Li, Satish Jalisatgi, M. Frederick Hawthorne.  “Synthesis of Vertex-Differentiated Icosahedral closo-Boranes: Polyfunctional Scaffolds for Targeted Drug Delivery.”  Journal of Organic Chemistry.  2012, 77 (24), 11333-11338.

Lalit Goswami, Lixin Ma, Shatadru Chakravarty, Quanyu Cai, Satish Jalisatgi, M. Frederick Hawthorne.  “Discrete Nanomolecular Polyhedral Borane Scaffold Supporting Multiple Gadolinium(III) Complexes as a High Performance MRI Contrast Agent.”  Inorg. Chem.  2013, 52 (4), 1694-1700.

Lalit Goswami, Zachary Houston, Satish S. Jalisatgi, M. Frederick Hawthorne.  “Efficient synthesis of diverse heterobifunctionalized clickable oligo (ethylene glycol) linkers for bioconjugation and drug delivery applications.”  Organic and Biomolecular Chemistry, 2012, 11, 1116-1126.

Oleg Bondarev, Yulia V. Sevryugina, Satish S. Jalisatgi, M. Frederick Hawthorne. “Acid-Induced Opening of [closo-B10H10]2- as a New Route to 6-Substituted nido-B10H13 Decaboranes and Related Carboranes.”  Inorg. Chem. 2012, 51, 9935-9942.

Alexander V. Safronov, Yulia V. Sevryugina, Satish S. Jalisatgi, Robert D. Kennedy, Charles L. Barnesand M. Frederick Hawthorne “An Unfairly Forgotten Member of the Iodocarborane Family: Synthesis and Structural Characterization of 8-Iodo-1,2-dicarba-closo-dodecaborane, Its Precursors and Derivatives.”  Inorg. Chem. 2012, 51, 2629-2637.

Satish S. Jalisatgi, Vikas S. Kulkarni, Betty Tang, Zachary H. Houston, Mark W. Lee and M. Frederick Hawthorne "A convenient route to diversely substituted icosahedral closomer nanoscaffolds." J. Am. Chem. Soc. 2011, 133, 12382-12385.

Lalit N. Goswami, Shatadru Chakravarty, Mark W. Lee, Satish S. Jalisatgi and M. Frederick Hawthorne "Extensions of the icosahedral closomer structure by using azide-alkyne click reactions." Angew. Chem. Int. Ed. Engl. 2011, 50, 4689-4691.

Alexander V. Safronov, Satish S. Jalisatgi, Han Baek Lee and M. Frederick Hawthorne "Chemical hydrogen storage using polynuclear borane anion salts." Int. J. Hydrogen Energy 2011, 36, 234-239.

Marina Chong, Abhi Karkamkar, Tom Autrey, Shin-ichi Orimo, Satish Jalisatgi and Craig M. Jensen "Reversible dehydrogenation of magnesium borohydride to magnesium triborane in the solid state under moderate conditions." Chem. Commun. (Camb) 2011, 47, 1330-1332.

Mark W. Lee, Jr., Alexander V. Safronov, Satish S. Jalisatgi, M. Frederick Hawthorne, Amartya Chakrabarti and Narayan Hosmane "Cesium dodecahydroxy-closo-dodecaborate, Cs2[B12(OH)12]." Inorg. Synth. 2010, 35, 63-66.

Muhammed Yousufuddin, Jae-Hyuk Her, Wei Zhou, Satish S. Jalisatgi and Terrence J. Udovic  "Crystal structure, neutron vibrational spectroscopy, and DFT calculations of Li2B12H12 4H2O." Inorg. Chim. Acta, 2009, 362, 3155-3158.

Michael F.Z. Page, Satish S. Jalisatgi, M. Frederick Hawthorne "Design and Synthesis of a Candidate α-Human Thrombin Irreversible Inhibitor Containing a Hydrophobic Carborane Pharmacophore" Synthesis, 2008, 555-563.

M. Frederick Hawthorne, Omar Farha, Richard Julius, Satish S. Jalisatgi, Tiejun Li, Michael J. Bayer "Polyhedral Boranes in Nanoworld", ACS symposium book series2006917: 312-324.

Tiejun Li, Satish S. Jalisatgi, Michael J. Bayer, Andreas Maderna, Saeed I. Khan, M. Frederick Hawthorne, "Organic Syntheses on an Aromatic Icosahedral Borane Surface: Closomer Structures with Twelvefold Functionality" J. Am. Chem. Soc., 2005127, 17832-17841.

Axel Herzog, Satish S. Jalisatgi, Timothy Wedge, Carolyn B. Knobler and M. Frederick Hawthorne "Camouflaged Carborarods Derived from B-Permethyl-1,12-diethyl-para-carborane and 1,7-Octamethyl-meta-Carborane Modules" J. Am. Chem. Soc.200511, 7155-7174.

Michael J. Bayer, Satish S. Jalisatgi, Brian Smart, Axel Herzog, Carolyn B. Knobler, M. Frederick Hawthorne "B-octamethyl-[12]Mercuracarborand-4 as Host for “Naked” Fluoride Ions", Angew. Chem. Int. Ed., 200443, 1854-1857.

Sriram Kumaraswamy; Satish S. Jalisatgi; Adam J. Matzger; Ognjen S. Miljanic; Vollhardt, K. Peter C. Vollhardt, "Anatomy of a Cyclohexatriene: Chemical Dissection of the π- and s-Frame of Angular [3]Phenylene" Angew. Chem. Int. Ed., 2004,43, 3711-3715.

M. Frederick Hawthorne, Cynthia L. Beno, David E. Harwell, Satish S. Jalisatgi and Carolyn B. Knobler "Intra- and inter-molecular hydrogen bonding in some cobaltacarboranes", J. Mol. Struc., 2003 239-247.

Yves Rubin, Timothy C. Parker, Salvador J. Pastor, Satish Jalisatgi, Christophe Boulle, and Charles L. Wilkins "Acetylenic Cyclophanes as Fullerene Precursors: Formation of C60H6 and C60 by Laser Desorption Mass Spectrometry of C60H6(CO)12" Angew. Chem. Int. Ed. 199837, 1226-1229.

Rainer Diercks, Bruce E. Eaton, Stefan Gürtzgen, Satish Jalisatgi, Adam J. Matzger, Rachel H. Radde, and K. Peter C. Vollhardt "The First Metallacyclopentadiene(Alkyne) Complexes and Their Discrete Isomerization to h4 Bound Arenes: The Missing Link in the Prevalent Mechanism of Transition Metal Catalyzed Alkyne Cyclotrimerizations, as Exemplified by Cyclopentadienylcobalt". J Am. Chem. Soc. 1998 120 8247-8248.

J. Kevin Cammack, Satish Jalisatgi, Adam J. Matzger, Alvin Negron and K. Peter C. Vollhardt "Room Temperature CpCo-Mediated Cyclization of a,d,w-Enediynes to Rearranging Strained Tricyclic Dienes: Some Observations of Kinetic versus Thermodynamic Control", J. Org. Chem. 1996 614798-4800.

Patents/Patent Applications

Safronov, A. V.; Jalisatgi, S. S.; Hawthorne, M. F. “Synthesis of borane compounds.” WO2015117119A1.

Safronov, A. V.; Jalisatgi, S. S.; Hawthorne, M. F. “Synthesis of amine boranes and polyhedral boranes” WO2015117123A1.